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    AlkB AlkB [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 2768870, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AlkBprovided by FlyBase
    Official Full Name
    AlkBprovided by FlyBase
    Primary source
    FLYBASE:FBgn0065035
    Locus tag
    Dmel_CG33250
    See related
    AllianceGenome:FB:FBgn0065035
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    alkB; BEST:LD02396; CG33250; Dmel\CG33250
    Summary
    Predicted to enable 2-oxoglutarate-dependent dioxygenase activity; class I DNA-(apurinic or apyrimidinic site) endonuclease activity; and ferrous iron binding activity. Predicted to be involved in oxidative RNA demethylation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; mesoderm; and posterior endoderm. Orthologous to human ALKBH1 (alkB homolog 1, histone H2A dioxygenase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See AlkB in Genome Data Viewer
    Location:
    13F14-13F16; 1-52 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15858134..15859487, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15752167..15753412, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ubiquitin like 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Myb oncogene-like Neighboring gene G protein beta subunit 13F Neighboring gene Glyceraldehyde 3 phosphate dehydrogenase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Alpha-ketoglutarate-dependent dioxygenase AlkB is involved in repair from neuronal disorders induced by ultraviolet damage. Wakisaka KT, et al. Neuroreport, 2019 Oct 16. PMID 31503204
    2. The DNA replication-related element-binding factor (DREF) is a transcriptional regulator of the Drosophila myb gene. Sharkov NV, et al. Gene, 2002 Sep 4. PMID 12384302
    3. Mutation of the Drosophila homologue of the Myb protooncogene causes genomic instability. Manak JR, et al. Proc Natl Acad Sci U S A, 2002 May 28. PMID 12032301, Free PMC Article
    4. Loss of Drosophila Myb interrupts the progression of chromosome condensation. Manak JR, et al. Nat Cell Biol, 2007 May. PMID 17450131
    5. Role for a Drosophila Myb-containing protein complex in site-specific DNA replication. Beall EL, et al. Nature, 2002 Dec 19-26. PMID 12490953

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila Alpha-ketoglutarate-dependent dioxygenase AlkB is involved in repair from neuronal disorders induced by ultraviolet damage.
      Title: Drosophila Alpha-ketoglutarate-dependent dioxygenase AlkB is involved in repair from neuronal disorders induced by ultraviolet damage.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables broad specificity oxidative DNA demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables broad specificity oxidative DNA demethylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ferrous iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidative RNA demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in oxidative RNA demethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    AlkB
    Names
    AlkB-PA
    AlkB-PB
    CG33250-PA
    CG33250-PB
    NP_001334682.1
    NP_996458.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15858134..15859487 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001347758.1 → NP_001334682.1  AlkB, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KUZ2

    2. NM_206735.2 → NP_996458.1  AlkB, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996458.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KUZ2
      Conserved Domains (1) summary
      cl21496
      Location:103 → 262
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KUZ2 Q7KUZ2

    Gene LinkOut

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