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    Sox21a Sox21a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39567, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Sox21aprovided by FlyBase
    Official Full Name
    Sox21aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036411
    Locus tag
    Dmel_CG7345
    See related
    AllianceGenome:FB:FBgn0036411
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7345; Dmel\CG7345; Sox B2-3; Sox21; sox21a; SoxB2.3; SOXB2.3
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in midgut development; negative regulation of cell differentiation; and stem cell proliferation. Located in nucleus. Is expressed in several structures, including enterocyte of posterior adult midgut epithelium; foregut primordium; hindgut proper primordium; somatic precursor cell; and ventral midline of embryo. Used to study intestinal cancer. Orthologous to human SOX14 (SRY-box transcription factor 14); SOX15 (SRY-box transcription factor 15); and SOX7 (SRY-box transcription factor 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sox21a in Genome Data Viewer
    Location:
    70D2-70D2; 3-42 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14103481..14108118, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14096581..14101218, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Fat body protein 1 Neighboring gene Sox21b Neighboring gene long non-coding RNA:CR45887

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of intestinal stem cell activity by a mitotic cell cycle regulator Polo in Drosophila. Zhang Y, et al. G3 (Bethesda), 2023 Jun 1. PMID 37154439, Free PMC Article
    2. A feedback amplification loop between stem cells and their progeny promotes tissue regeneration and tumorigenesis. Chen J, et al. Elife, 2016 May 17. PMID 27187149, Free PMC Article
    3. Conserved genomic organisation of Group B Sox genes in insects. McKimmie C, et al. BMC Genet, 2005 May 19. PMID 15943880, Free PMC Article
    4. A Sox Transcription Factor Is a Critical Regulator of Adult Stem Cell Proliferation in the Drosophila Intestine. Meng FW, et al. Cell Rep, 2015 Nov 3. PMID 26565904
    5. Aging-related upregulation of the homeobox gene caudal represses intestinal stem cell differentiation in Drosophila. Wu K, et al. PLoS Genet, 2021 Jul. PMID 34228720, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We further demonstrate that JAK/STAT signaling, Sox21a and GATAe form a functional relay to orchestrate EB differentiation. Thus, our study provides new insights into the complex and sequential events that are required for rapid differentiation following stem cell division during tissue replenishment.
      Title: A genetic framework controlling the differentiation of intestinal stem cells during regeneration in Drosophila.
    2. Sox21a is specifically required for adult intestinal stem cell proliferation.
      Title: A Sox Transcription Factor Is a Critical Regulator of Adult Stem Cell Proliferation in the Drosophila Intestine.
    3. This study reports that loss of the SOX transcription factor, Sox21a, blocks the differentiation programme of enteroblast (EB), the intestinal stem cell progeny in the adult Drosophila midgut with subsequent tumor formation.
      Title: Accumulation of differentiating intestinal stem cell progenies drives tumorigenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in midgut development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sox21a
    Names
    CG7345-PA
    CG7345-PB
    Sox21a-PA
    Sox21a-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      14103481..14108118 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140437.2 → NP_648694.1  Sox21a, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648694.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUD1
      Related
      FBpp0075490
      Conserved Domains (1) summary
      cd01388
      Location:120 → 191
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

    2. NM_001274898.1 → NP_001261827.1  Sox21a, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261827.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFG6
      Conserved Domains (1) summary
      cd01388
      Location:120 → 191
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PFG6 M9PFG6
    Q9VUD1 Q9VUD1

    Gene LinkOut

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