croc crocodile [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: crocprovided by FlyBase
Official Full Name: crocodileprovided by FlyBase
Primary source: FLYBASE:FBgn0014143
Locus tag: Dmel_CG5069
See related: AllianceGenome:FB:FBgn0014143
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5069; Croc; Dm-FoxC; Dmel\CG5069; Dmfd1; fd1; FD1; fd78E; FoxC
Summary: Enables DNA binding activity. Involved in specification of segmental identity, head. Located in nucleus. Is expressed in several structures, including anterior-posterior subdivision of organism; gut section; head epidermis primordium; mesoderm; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in several diseases, including eye disease (multiple); lymphedema; lymphedema-distichiasis syndrome; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including FOXC2 (forkhead box C2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (21474133..21476479, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (21467233..21469579, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in specification of segmental identity, head	IMP Inferred from Mutant Phenotype more info	PubMed