S6k Ribosomal protein S6 kinase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: S6kprovided by FlyBase
Official Full Name: Ribosomal protein S6 kinaseprovided by FlyBase
Primary source: FLYBASE:FBgn0283472
Locus tag: Dmel_CG10539
See related: AllianceGenome:FB:FBgn0283472
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 10539; 7-10; 7084; CG10539; d-S6K; Dmel\CG10539; dp70s6k; dP70S6K; Dp70s6k; Dp70S6k; dp70[S6k]; Dp70[s6k]; dps6k; ds6k; dS6k; dS6K; DS6K; dS6K1; fs(3)07084; l(3)07084; p-S6K; p70 S6K; p70/S6K; p70s6K; p70S6k; p70S6K; p70[S6 kinase]; p70[S6kinase]; p70[S6k]; p70[S6K]; Pk64F; Pk?6; pS6K; S6; S6 K; s6k; S6K; S6K1; s6k11
Summary: Enables ribosomal protein S6 kinase activity. Involved in several processes, including TORC1 signaling; cell surface receptor protein tyrosine kinase signaling pathway; and nervous system development. Located in presynaptic active zone. Is expressed in adult brain and adult head. Used to study alcohol dependence; glucose metabolism disease; and type 2 diabetes mellitus. Orthologous to human RPS6KB1 (ribosomal protein S6 kinase B1) and RPS6KB2 (ribosomal protein S6 kinase B2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 64E8-64E11; 3-15 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (5797549..5810931, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (5790649..5804031, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glutamine stimulates the S6K/4E-BP branch of insulin signalling pathway to mitigate human poly(Q) disorders in Drosophila disease models.
Title: Glutamine stimulates the S6K/4E-BP branch of insulin signalling pathway to mitigate human poly(Q) disorders in Drosophila disease models.
Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system.
Title: Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system.
Identification of PP2A and S6 Kinase as Modifiers of Leucine-Rich Repeat Kinase-Induced Neurotoxicity.
Title: Identification of PP2A and S6 Kinase as Modifiers of Leucine-Rich Repeat Kinase-Induced Neurotoxicity.
The S6k/4E-BP mediated growth promoting sub-pathway of insulin signalling cascade is essential to restrict pathogenesis of poly(Q) disorders in Drosophila.
Title: The S6k/4E-BP mediated growth promoting sub-pathway of insulin signalling cascade is essential to restrict pathogenesis of poly(Q) disorders in Drosophila.
mTOR-S6K1 pathway mediates cytoophidium assembly
Title: mTOR-S6K1 pathway mediates cytoophidium assembly.
Findings indicate that Archipelago (Ago)/FBXW7 controls S6kinase (dS6K) protein levels, but do not impinge on the transcript level.
Title: A Drosophila genetic screen for suppressors of S6kinase-dependent growth identifies the F-box subunit Archipelago/FBXW7.
MYC and S6K cooperate through coordinate activation of the essential Pol I transcription initiation factor TIF-1A.
Title: S6 Kinase is essential for MYC-dependent rDNA transcription in Drosophila.
This study showed that p70 S6 kinase (S6k), acting downstream of the insulin receptor (InR) and the small GTPase Arf6, is a key mediator of ethanol-induced sedation in Drosophila
Title: S6 Kinase Reflects and Regulates Ethanol-Induced Sedation.
our results indicate that S6K1 has an inhibitory effect on autophagic activity under normal nutritional conditions
Title: TAK1 regulates autophagic cell death by suppressing the phosphorylation of p70 S6 kinase 1.
S6 kinase localizes to the presynaptic active zone and functions with PDK1 to control synapse development
Title: S6 kinase localizes to the presynaptic active zone and functions with PDK1 to control synapse development.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables ribosomal protein S6 kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables ribosomal protein S6 kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in TORC1 signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to amino acid stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell size	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of response to drug	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of terminal button organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	HDA more info	PubMed
located_in nucleoplasm	HDA more info	PubMed
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ribosomal protein S6 kinase

Names: CG10539-PA; CG10539-PB; RPS6-p70-protein kinase; S6 kinase; S6-kinase; S6K kinase; S6k-PA; S6k-PB; S6kinase; dS6 kinase; p70 S6 kinase; p70 S6 kinase 1; p70 ribosomal S6 kinase; p70S6 kinase; p70S6K kinase; protein kinase-like 64F; ribosomal S6 protein kinase

NP_001261450.1

EC 2.7.11.1

NP_523941.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

5797549..5810931 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274521.1 → NP_001261450.1 ribosomal protein S6 kinase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261450.1

Status: REVIEWED

UniProtKB/TrEMBL

H1ZYE3, Q94533

Conserved Domains (2) summary

PTZ00263
Location:76 → 397

PTZ00263; protein kinase A catalytic subunit; Provisional

cd05584
Location:81 → 402

STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
NM_079217.3 → NP_523941.2 ribosomal protein S6 kinase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523941.2

Status: REVIEWED

UniProtKB/TrEMBL

H1ZYE3, Q94533

Related

FBpp0076820

Conserved Domains (2) summary

PTZ00263
Location:76 → 397

PTZ00263; protein kinase A catalytic subunit; Provisional

cd05584
Location:81 → 402

STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase