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    AhcyL2 Adenosylhomocysteinase like 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42043, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AhcyL2provided by FlyBase
    Official Full Name
    Adenosylhomocysteinase like 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0015011
    Locus tag
    Dmel_CG8956
    See related
    AllianceGenome:FB:FBgn0015011
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AHCY; Ahcy89E; CG8956; dAhcyL2; Dmel\CG8956; IRBIT2; pH200; S-AHCY
    Summary
    Predicted to be involved in S-adenosylmethionine cycle. Predicted to be active in cytosol. Is expressed in several structures, including adult head; amnioserosa; embryonic/larval crystal cell; embryonic/larval garland cell; and fat body. Orthologous to human AHCYL1 (adenosylhomocysteinase like 1) and AHCYL2 (adenosylhomocysteinase like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See AhcyL2 in Genome Data Viewer
    Location:
    89E5-89E5; 3-59 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16978439..16982158, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12804161..12807880, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Vacuolar H[+] ATPase M9.7 subunit d Neighboring gene alpha actinin 3 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45592 Neighboring gene Misexpression suppressor of KSR 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The S-adenosyl-L-homocysteine hydrolase of Drosophila melanogaster: identification, deduced amino acid sequence and cytological localization of the structural gene. Caggese C, et al. Mol Gen Genet, 1997 Jan 27. PMID 9037110
    2. Evidence that the Abdominal-B r element function is conferred by a trans-regulatory homeoprotein. DeLorenzi M, et al. EMBO J, 1988 Oct. PMID 2903049, Free PMC Article
    3. IRBIT Directs Differentiation of Intestinal Stem Cell Progeny to Maintain Tissue Homeostasis. Arnaoutov A, et al. iScience, 2020 Mar 27. PMID 32179478, Free PMC Article
    4. A basal transcription factor that activates or represses transcription. Willy PJ, et al. Science, 2000 Nov 3. PMID 11062130
    5. Mathematical model to predict regions of chromatin attachment to the nuclear matrix. Singh GB, et al. Nucleic Acids Res, 1997 Apr 1. PMID 9060438, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables adenosylhomocysteinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables adenosylhomocysteinase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in S-adenosylmethionine cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adenosylhomocysteinase like 2
    Names
    AdoHcyase-like
    AhcyL2-PC
    AhcyL2-PD
    CG8956-PC
    CG8956-PD
    S-adenosyl homocysteine hydrolase-like
    adenosylhomocysteinase 89E

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16978439..16982158 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206499.2 → NP_996221.1  adenosylhomocysteinase like 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996221.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KSG0
      Conserved Domains (2) summary
      PRK05476
      Location:63 → 486
      PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional
      pfam05221
      Location:67 → 491
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase

    2. NM_206500.2 → NP_996222.1  adenosylhomocysteinase like 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996222.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P50245, Q27587, Q8MYX7, Q9VEQ4
      Conserved Domains (2) summary
      PRK05476
      Location:63 → 486
      PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional
      pfam05221
      Location:67 → 491
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50245.2 P50245
    Q7KSG0 Q7KSG0

    Gene LinkOut

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