U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    blp black pearl [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41937, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    blpprovided by FlyBase
    Official Full Name
    black pearlprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038387
    Locus tag
    Dmel_CG5268
    See related
    AllianceGenome:FB:FBgn0038387
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE11908; Blp; CG5268; Dmel\CG5268; l(3)01618
    Summary
    Involved in instar larval development. Predicted to be part of TIM23 mitochondrial import inner membrane translocase complex. Is expressed in several structures, including adult heart; embryonic/larval midgut; embryonic/larval midgut primordium; ganglia; and head. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia Megarbane-Dagher-Melike type. Orthologous to human PAM16 (presequence translocase associated motor 16). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See blp in Genome Data Viewer
    Location:
    89A8-89A8; 3-58 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15933847..15934940)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11759569..11760662)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene F-box and leucine-rich repeat protein 7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Synapse-associated protein 47kD Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Essential role of Drosophila black-pearl is mediated by its effects on mitochondrial respiration. Roy S, et al. FASEB J, 2012 Sep. PMID 22700875, Free PMC Article
    2. The black-pearl gene of Drosophila defines a novel conserved protein family and is required for larval growth and survival. Becker S, et al. Gene, 2001 Jan 10. PMID 11179663
    3. The Histone Demethylase KDM5 Activates Gene Expression by Recognizing Chromatin Context through Its PHD Reader Motif. Liu X, et al. Cell Rep, 2015 Dec 15. PMID 26673323, Free PMC Article
    4. The Drosophila fork head domain protein crocodile is required for the establishment of head structures. Häcker U, et al. EMBO J, 1995 Nov 1. PMID 7489720, Free PMC Article
    5. Heat shock protein 83 (Hsp83) facilitates methoprene-tolerant (Met) nuclear import to modulate juvenile hormone signaling. He Q, et al. J Biol Chem, 2014 Oct 3. PMID 25122763, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in instar larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of TIM23 mitochondrial import inner membrane translocase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TIM23 mitochondrial import inner membrane translocase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    black pearl
    Names
    CG5268-PA
    CG5268-PB
    black-pearl
    blp-PA
    blp-PB

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15933847..15934940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300420.1 → NP_001287349.1  black pearl, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287349.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9GP65, Q9VF08
      UniProtKB/TrEMBL
      A0A0B4LH72
      Conserved Domains (1) summary
      cl02542
      Location:1 → 117
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

    2. NM_079646.4 → NP_524370.2  black pearl, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524370.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9GP65, Q9VF08
      UniProtKB/TrEMBL
      A0A0B4LH72
      Related
      FBpp0082657
      Conserved Domains (1) summary
      cl02542
      Location:1 → 117
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LH72 A0A0B4LH72
    Q9VF08.1 Q9VF08

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools