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    lili lilipod [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42956, updated on 9-Dec-2024

    Summary

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    Official Symbol
    liliprovided by FlyBase
    Official Full Name
    lilipodprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027539
    Locus tag
    Dmel_CG5807
    See related
    AllianceGenome:FB:FBgn0027539
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.355; BcDNA:GH12663; CG5807; Dmel\CG5807
    Summary
    Predicted to enable transmembrane signaling receptor activity. Involved in female germ-line stem cell population maintenance and positive regulation of BMP signaling pathway. Predicted to be active in plasma membrane. Is expressed in female germline stem cell and follicle cell. Human ortholog(s) of this gene implicated in Laurin-Sandrow syndrome; acheiropody; and syndactyly type 4. Orthologous to human LMBR1 (limb development membrane protein 1) and LMBR1L (limb development membrane protein 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See lili in Genome Data Viewer
    Location:
    96A23-96A23; 3-85 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24805445..24814012, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20631167..20639734, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Ets96B Neighboring gene Uracil-DNA degrading factor Neighboring gene polybromo Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46096 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High-resolution SNP mapping by denaturing HPLC. Nairz K, et al. Proc Natl Acad Sci U S A, 2002 Aug 6. PMID 12149455, Free PMC Article
    2. Fly LMBR1/LIMR-type protein Lilipod promotes germ-line stem cell self-renewal by enhancing BMP signaling. Dolezal D, et al. Proc Natl Acad Sci U S A, 2015 Nov 10. PMID 26512105, Free PMC Article
    3. Effects of tethering HP1 to euchromatic regions of the Drosophila genome. Li Y, et al. Development, 2003 May. PMID 12642487
    4. NELF and GAGA factor are linked to promoter-proximal pausing at many genes in Drosophila. Lee C, et al. Mol Cell Biol, 2008 May. PMID 18332113, Free PMC Article
    5. Nicastrin controls aspects of photoreceptor neuron specification and differentiation in the Drosophila eye. Zhang T, et al. Dev Dyn, 2005 Nov. PMID 16145661

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in female germ-line stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of BMP signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    lilipod
    Names
    CG5807-PA
    CG5807-PB
    LIMR-like promoter of ovarian dpp
    lili-PA
    lili-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24805445..24814012 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276001.1 → NP_001262930.1  lilipod, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262930.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGZ8
      Conserved Domains (1) summary
      pfam04791
      Location:63 → 495
      LMBR1; LMBR1-like membrane protein

    2. NM_143033.3 → NP_651290.1  lilipod, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651290.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86PC4, Q9VC35, Q9XZ04
      Related
      FBpp0084114
      Conserved Domains (1) summary
      pfam04791
      Location:63 → 495
      LMBR1; LMBR1-like membrane protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGZ8 A0A0B4KGZ8
    Q9VC35.1 Q9VC35

    Gene LinkOut

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