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    Las Lipoic acid synthase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40259, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lasprovided by FlyBase
    Official Full Name
    Lipoic acid synthaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029158
    Locus tag
    Dmel_CG5231
    See related
    AllianceGenome:FB:FBgn0029158
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5231; Dmel\CG5231
    Summary
    Predicted to enable lipoate synthase activity. Predicted to be involved in lipoate biosynthetic process. Predicted to be active in mitochondrion. Is expressed in embryonic/larval fat body and organism. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human LIAS (lipoic acid synthetase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Las in Genome Data Viewer
    Location:
    77C2-77C3; 3-47 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20430605..20432361, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20423705..20425461, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Presenilin Neighboring gene mitochondrial ribosomal protein L15 Neighboring gene CTBP-interacting protein Neighboring gene 4-hydroxyphenylpyruvate dioxygenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lipoic acid rejuvenates aged intestinal stem cells by preventing age-associated endosome reduction. Du G, et al. EMBO Rep, 2020 Aug 5. PMID 32648369, Free PMC Article
    2. Drosophila presenilin is required for neuronal differentiation and affects notch subcellular localization and signaling. Guo Y, et al. J Neurosci, 1999 Oct 1. PMID 10493744, Free PMC Article
    3. Genome-wide analysis of nuclear mRNA export pathways in Drosophila. Herold A, et al. EMBO J, 2003 May 15. PMID 12743041, Free PMC Article
    4. Expression of cardiac myosin-binding protein-C (cMyBP-C) in Drosophila as a model for the study of human cardiomyopathies. Vu Manh TP, et al. Hum Mol Genet, 2005 Jan 1. PMID 15525659
    5. Cdk8 attenuates lipogenesis by inhibiting SREBP-dependent transcription in Drosophila. Li X, et al. Dis Model Mech, 2022 Nov 1. PMID 36305265, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipoate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipoate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipoate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipoate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lipoic acid synthase
    Names
    CG5231-PC
    Las-PC
    NP_524183.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20430605..20432361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079459.3 → NP_524183.2  lipoic acid synthase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524183.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JQW6, Q9VPF7
      Conserved Domains (3) summary
      cd01335
      Location:131 → 307
      Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
      PLN02428
      Location:19 → 368
      PLN02428; lipoic acid synthase
      pfam16881
      Location:3 → 108
      LIAS_N; N-terminal domain of lipoyl synthase of Radical_SAM family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JQW6.2 Q7JQW6

    Gene LinkOut

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