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    Alg14 ALG14, UDP-N-acetylglucosaminyltransferase subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362031, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Alg14provided by RGD
    Official Full Name
    ALG14, UDP-N-acetylglucosaminyltransferase subunitprovided by RGD
    Primary source
    RGD:1312003
    See related
    EnsemblRapid:ENSRNOG00000011528 AllianceGenome:RGD:1312003
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1312003
    Summary
    Predicted to enable protein-membrane adaptor activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to act upstream of with a positive effect on protein N-linked glycosylation. Predicted to be part of UDP-N-acetylglucosamine transferase complex. Predicted to be active in cytoplasmic side of endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 15. Orthologous to human ALG14 (ALG14 UDP-N-acetylglucosaminyltransferase subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 95.8), Lung (RPKM 86.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Alg14 in Genome Data Viewer
    Location:
    2q42
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (212053008..212130136)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (209368285..209445425)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (224851352..224931461)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene TLC domain containing 4 Neighboring gene ribosomal protein S19, pseudogene 5 Neighboring gene uncharacterized LOC120100935 Neighboring gene uncharacterized LOC103691685

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-membrane adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-membrane adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in dolichol-linked oligosaccharide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dolichol-linked oligosaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dolichol-linked oligosaccharide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dolichol-linked oligosaccharide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_positive_effect protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_positive_effect protein N-linked glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of UDP-N-acetylglucosamine transferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of UDP-N-acetylglucosamine transferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of UDP-N-acetylglucosamine transferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of UDP-N-acetylglucosamine transferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic side of endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic side of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic side of endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    UDP-N-acetylglucosamine transferase subunit ALG14; UDP-N-acetylglucosamine transferase subunit ALG14 homolog
    Names
    asparagine-linked glycosylation 14 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014176.2 → NP_001014198.1  UDP-N-acetylglucosamine transferase subunit ALG14

      See identical proteins and their annotated locations for NP_001014198.1

      Status: VALIDATED

      Source sequence(s)
      BC079151, BI292249, CO400199
      UniProtKB/Swiss-Prot
      Q6AY85
      UniProtKB/TrEMBL
      A0A8L2UIZ1, A6HVD6
      Conserved Domains (1) summary
      pfam08660
      Location:39 → 215
      Alg14; Oligosaccharide biosynthesis protein Alg14 like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      212053008..212130136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233243.5 → XP_006233305.1  UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform X3

      Conserved Domains (1) summary
      cl10013
      Location:39 → 94
      Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

    2. XM_017590978.3 → XP_017446467.1  UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform X3

      Conserved Domains (1) summary
      cl10013
      Location:39 → 94
      Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

    3. XM_008761465.3 → XP_008759687.1  UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform X1

      Conserved Domains (1) summary
      cl10013
      Location:39 → 262
      Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

    4. XM_039102713.2 → XP_038958641.1  UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform X4

      Conserved Domains (1) summary
      cl10013
      Location:39 → 94
      Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology

    5. XM_039102714.2 → XP_038958642.1  UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform X5

      Conserved Domains (1) summary
      cl10013
      Location:39 → 94
      Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology

    6. XM_008761466.4 → XP_008759688.1  UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform X2

      Related
      ENSRNOP00000015355.6, ENSRNOT00000015354.7
      Conserved Domains (1) summary
      cl10013
      Location:39 → 140
      Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

    7. XM_039102715.2 → XP_038958643.1  UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform X6

      Conserved Domains (1) summary
      cl10013
      Location:39 → 140
      Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology

    RNA

    1. XR_005500319.2 RNA Sequence

    2. XR_010063627.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AY85.1 GenPept UniProtKB/Swiss-Prot:Q6AY85

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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