U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Xpnpep1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble [ Mus musculus (house mouse) ]

    Gene ID: 170750, updated on 9-Dec-2024

    Summary

    Official Symbol
    Xpnpep1provided by MGI
    Official Full Name
    X-prolyl aminopeptidase (aminopeptidase P) 1, solubleprovided by MGI
    Primary source
    MGI:MGI:2180003
    See related
    Ensembl:ENSMUSG00000025027 AllianceGenome:MGI:2180003
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    sAMP; D230045I08Rik
    Summary
    Predicted to enable manganese ion binding activity; metalloaminopeptidase activity; and protein homodimerization activity. Predicted to be involved in bradykinin catabolic process; negative regulation of programmed cell death; and proteolysis. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human XPNPEP1 (X-prolyl aminopeptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 157.6), small intestine adult (RPKM 86.1) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Xpnpep1 in Genome Data Viewer
    Location:
    19 D2; 19 46.91 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (52919710..53027093, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (52931279..53038662, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41860 Neighboring gene STARR-seq mESC enhancer starr_46416 Neighboring gene STARR-seq mESC enhancer starr_46417 Neighboring gene STARR-seq mESC enhancer starr_46418 Neighboring gene STARR-seq mESC enhancer starr_46419 Neighboring gene STARR-seq mESC enhancer starr_46420 Neighboring gene expressed sequence AA387883 Neighboring gene predicted gene, 41861 Neighboring gene STARR-positive B cell enhancer ABC_E7671 Neighboring gene STARR-seq mESC enhancer starr_46426 Neighboring gene STARR-seq mESC enhancer starr_46431 Neighboring gene microRNA 6407 Neighboring gene STARR-seq mESC enhancer starr_46433 Neighboring gene RIKEN cDNA 1700054A03 gene Neighboring gene predicted gene, 54048 Neighboring gene predicted gene, 30234

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables aminopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables manganese ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metalloaminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metalloaminopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in bradykinin catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bradykinin catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of programmed cell death ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    xaa-Pro aminopeptidase 1
    Names
    X-Pro aminopeptidase 1
    aminoacylproline aminopeptidase
    cytosolic aminopeptidase P
    NP_001361763.1
    NP_573479.3
    XP_011245460.1
    XP_011245461.1
    XP_017173564.1
    XP_030106621.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374834.1NP_001361763.1  xaa-Pro aminopeptidase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC163221
      Consensus CDS
      CCDS89415.1
      UniProtKB/Swiss-Prot
      Q6P1B1, Q91Y37
      UniProtKB/TrEMBL
      Q3TL27, Q3UKF5
      Conserved Domains (4) summary
      cd01085
      Location:329551
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam16188
      Location:557618
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:157326
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain
      cl23800
      Location:10154
      Creatinase_N; Creatinase/Prolidase N-terminal domain
    2. NM_133216.4NP_573479.3  xaa-Pro aminopeptidase 1 isoform 1

      See identical proteins and their annotated locations for NP_573479.3

      Status: VALIDATED

      Source sequence(s)
      AC163221
      Consensus CDS
      CCDS29899.2
      UniProtKB/TrEMBL
      Q3UE92, S4R1I3
      Related
      ENSMUSP00000138250.2, ENSMUST00000183108.8
      Conserved Domains (4) summary
      cd01085
      Location:372594
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam16188
      Location:600661
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:200369
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain
      cl23800
      Location:53197
      Creatinase_N; Creatinase/Prolidase N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      52919710..53027093 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247158.3XP_011245460.1  xaa-Pro aminopeptidase 1 isoform X1

      UniProtKB/TrEMBL
      S4R1I3
      Conserved Domains (4) summary
      cd01085
      Location:372594
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam16188
      Location:600624
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:200369
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain
      cl23800
      Location:53197
      Creatinase_N; Creatinase/Prolidase N-terminal domain
    2. XM_030250761.2XP_030106621.1  xaa-Pro aminopeptidase 1 isoform X3

      UniProtKB/TrEMBL
      A0A494BBG8, Q3TL27
      Related
      ENSMUSP00000158501.2, ENSMUST00000236008.2
      Conserved Domains (4) summary
      cd01085
      Location:329551
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam16188
      Location:557581
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:157326
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain
      cl23800
      Location:10154
      Creatinase_N; Creatinase/Prolidase N-terminal domain
    3. XM_011247159.2XP_011245461.1  xaa-Pro aminopeptidase 1 isoform X2

      See identical proteins and their annotated locations for XP_011245461.1

      UniProtKB/Swiss-Prot
      Q6P1B1, Q91Y37
      UniProtKB/TrEMBL
      Q3TL27, Q3UKF5
      Related
      ENSMUSP00000158390.2, ENSMUST00000237294.2
      Conserved Domains (4) summary
      cd01085
      Location:329551
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam16188
      Location:557618
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:157326
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain
      cl23800
      Location:10154
      Creatinase_N; Creatinase/Prolidase N-terminal domain
    4. XM_017318075.3XP_017173564.1  xaa-Pro aminopeptidase 1 isoform X4

      UniProtKB/TrEMBL
      Q3TL27
      Related
      ENSMUST00000182877.8
      Conserved Domains (3) summary
      cd01085
      Location:258480
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam16188
      Location:486547
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:86255
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain