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    Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 12614, updated on 9-Dec-2024

    Summary

    Official Symbol
    Celsr1provided by MGI
    Official Full Name
    cadherin, EGF LAG seven-pass G-type receptor 1provided by MGI
    Primary source
    MGI:MGI:1100883
    See related
    Ensembl:ENSMUSG00000016028 AllianceGenome:MGI:1100883
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Scy; Crsh; crash; Adgrc1
    Summary
    Predicted to enable calcium ion binding activity. Involved in establishment of planar polarity and neural tube closure. Acts upstream of or within several processes, including apical protein localization; morphogenesis of an epithelium; and motor neuron migration. Located in membrane. Is expressed in several structures, including central nervous system; epithelium; primitive streak; renal cortex; and skin. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human CELSR1 (cadherin EGF LAG seven-pass G-type receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in colon adult (RPKM 9.9), ovary adult (RPKM 9.8) and 18 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Celsr1 in Genome Data Viewer
    Location:
    15 E2; 15 40.42 cM
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (85782959..85918424, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (85898758..86034223, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39401 Neighboring gene STARR-positive B cell enhancer ABC_E4144 Neighboring gene G two S phase expressed protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E10874 Neighboring gene tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase Neighboring gene STARR-seq mESC enhancer starr_39409 Neighboring gene predicted gene, 34764 Neighboring gene predicted gene, 41375 Neighboring gene GRAM domain containing 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within anterior/posterior pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within apical protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within establishment of body hair planar orientation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of planar polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within establishment of planar polarity of embryonic epithelium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hair follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within inner ear morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lateral sprouting involved in lung morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within motor neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neural tube closure IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within planar dichotomous subdivision of terminal units involved in lung branching morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein localization involved in establishment of planar polarity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within wound healing IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cadherin EGF LAG seven-pass G-type receptor 1
    Names
    cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
    seven-pass transmembrane receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009886.2NP_034016.2  cadherin EGF LAG seven-pass G-type receptor 1 precursor

      See identical proteins and their annotated locations for NP_034016.2

      Status: VALIDATED

      Source sequence(s)
      AC116764, AC139513, AF031572, BQ180311, BQ942572, CV561900
      Consensus CDS
      CCDS37172.1
      UniProtKB/Swiss-Prot
      E9QK27, O35161
      Related
      ENSMUSP00000016172.8, ENSMUST00000016172.10
      Conserved Domains (10) summary
      smart00303
      Location:24222475
      GPS; G-protein-coupled receptor proteolytic site domain
      cd11304
      Location:808903
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00008
      Location:20672128
      HormR; Domain present in hormone receptors
      cd00054
      Location:18891923
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:20172055
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:14591642
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00002
      Location:24812712
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02210
      Location:17341864
      Laminin_G_2; Laminin G domain
      pfam16489
      Location:21462394
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl22855
      Location:19302026
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      85782959..85918424 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248310.1XP_030104170.1  cadherin EGF LAG seven-pass G-type receptor 1 isoform X3

      Conserved Domains (11) summary
      smart00303
      Location:24222475
      GPS; G-protein-coupled receptor proteolytic site domain
      cd11304
      Location:808903
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00008
      Location:20672128
      HormR; Domain present in hormone receptors
      cd00054
      Location:18891923
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:20172055
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:14591642
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cd00185
      Location:19512000
      TNFRSF; CRD3 [structural motif]
      cd15991
      Location:24802733
      7tmB2_CELSR1; Cadherin EGF LAG seven-pass G-type receptor 1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02210
      Location:17341861
      Laminin_G_2; Laminin G domain
      pfam16489
      Location:21452396
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl22855
      Location:19302026
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    2. XM_006520380.2XP_006520443.1  cadherin EGF LAG seven-pass G-type receptor 1 isoform X2

      Conserved Domains (11) summary
      smart00303
      Location:24222475
      GPS; G-protein-coupled receptor proteolytic site domain
      cd11304
      Location:808903
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00008
      Location:20672128
      HormR; Domain present in hormone receptors
      cd00054
      Location:18891923
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:20172055
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:14591642
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cd00185
      Location:19512000
      TNFRSF; CRD3 [structural motif]
      cd15991
      Location:24802733
      7tmB2_CELSR1; Cadherin EGF LAG seven-pass G-type receptor 1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02210
      Location:17341861
      Laminin_G_2; Laminin G domain
      pfam16489
      Location:21452396
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl22855
      Location:19302026
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    3. XM_006520379.2XP_006520442.1  cadherin EGF LAG seven-pass G-type receptor 1 isoform X1

      Conserved Domains (11) summary
      smart00303
      Location:24222475
      GPS; G-protein-coupled receptor proteolytic site domain
      cd11304
      Location:808903
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00008
      Location:20672128
      HormR; Domain present in hormone receptors
      cd00054
      Location:18891923
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:20172055
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:14591642
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cd00185
      Location:19512000
      TNFRSF; CRD3 [structural motif]
      cd15991
      Location:24802733
      7tmB2_CELSR1; Cadherin EGF LAG seven-pass G-type receptor 1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02210
      Location:17341861
      Laminin_G_2; Laminin G domain
      pfam16489
      Location:21452396
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl22855
      Location:19302026
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    4. XM_006520381.3XP_006520444.1  cadherin EGF LAG seven-pass G-type receptor 1 isoform X4

      Conserved Domains (11) summary
      smart00303
      Location:24222475
      GPS; G-protein-coupled receptor proteolytic site domain
      cd11304
      Location:808903
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00008
      Location:20672128
      HormR; Domain present in hormone receptors
      cd00054
      Location:18891923
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:20172055
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:14591642
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cd00185
      Location:19512000
      TNFRSF; CRD3 [structural motif]
      cd15991
      Location:24802733
      7tmB2_CELSR1; Cadherin EGF LAG seven-pass G-type receptor 1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02210
      Location:17341861
      Laminin_G_2; Laminin G domain
      pfam16489
      Location:21452396
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl22855
      Location:19302026
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    5. XM_006520382.4XP_006520445.1  cadherin EGF LAG seven-pass G-type receptor 1 isoform X5

      UniProtKB/TrEMBL
      A0A2I3BPU9
      Related
      ENSMUSP00000153927.2, ENSMUST00000226840.2
      Conserved Domains (10) summary
      smart00303
      Location:12061259
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:851912
      HormR; Domain present in hormone receptors
      smart00179
      Location:206240
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:673707
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:801839
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:243426
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cd14964
      Location:12661291
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam02210
      Location:518645
      Laminin_G_2; Laminin G domain
      pfam16489
      Location:9291180
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl28897
      Location:12641517
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    6. XM_036159109.1XP_036015002.1  cadherin EGF LAG seven-pass G-type receptor 1 isoform X6

      Conserved Domains (3) summary
      cd11304
      Location:808903
      Cadherin_repeat; Cadherin tandem repeat domain
      cd00054
      Location:13791414
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:14591642
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...