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    Wnt3 wingless-type MMTV integration site family, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 22415, updated on 27-Nov-2024

    Summary

    Official Symbol
    Wnt3provided by MGI
    Official Full Name
    wingless-type MMTV integration site family, member 3provided by MGI
    Primary source
    MGI:MGI:98955
    See related
    Ensembl:ENSMUSG00000000125 AllianceGenome:MGI:98955
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Int-4; Wnt-3
    Summary
    Enables protein domain specific binding activity. Involved in positive regulation of Wnt signaling pathway. Acts upstream of or within several processes, including axis specification; embryonic morphogenesis; and regulation of extent of cell growth. Located in extracellular matrix. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; embryo ectoderm; and sensory organ. Human ortholog(s) of this gene implicated in tetraamelia syndrome 1. Orthologous to human WNT3 (Wnt family member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 13.8), limb E14.5 (RPKM 4.0) and 8 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Wnt3 in Genome Data Viewer
    Location:
    11 E1; 11 67.5 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (103665000..103708854)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (103774175..103818021)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene reprimo-like Neighboring gene RIKEN cDNA C130046K22 gene Neighboring gene golgi SNAP receptor complex member 2 Neighboring gene wingless-type MMTV integration site family, member 9B Neighboring gene STARR-seq mESC enhancer starr_30857 Neighboring gene STARR-seq mESC enhancer starr_30858 Neighboring gene STARR-seq mESC enhancer starr_30861 Neighboring gene VISTA enhancer mm1102 Neighboring gene N-ethylmaleimide sensitive fusion protein Neighboring gene predicted gene, 35365 Neighboring gene CDGSH iron-sulfur domain-containing protein 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables frizzled binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables frizzled binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables frizzled binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor ligand activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Spemann organizer formation at the anterior end of the primitive streak IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within anatomical structure formation involved in morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within animal organ morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within anterior/posterior axis specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within anterior/posterior pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within axon guidance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within dorsal/ventral axis specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic forelimb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic hindlimb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within gamete generation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within head morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in limb bud formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in limb bud formation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within limb development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mammary gland epithelium development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mesoderm formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in midbrain dopaminergic neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in midbrain dopaminergic neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of axon extension involved in axon guidance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of collateral sprouting in absence of injury IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mesenchymal stem cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of mesenchymal stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in stem cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    proto-oncogene Wnt-3
    Names
    proto-oncogene Int-4
    proto-oncogene protein Wnt-3
    wingless-related MMTV integration site 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009521.3NP_033547.1  proto-oncogene Wnt-3 precursor

      See identical proteins and their annotated locations for NP_033547.1

      Status: VALIDATED

      Source sequence(s)
      AL596108
      Consensus CDS
      CCDS25523.1
      UniProtKB/Swiss-Prot
      P17553
      UniProtKB/TrEMBL
      A2A649, Q8BLT2
      Related
      ENSMUSP00000000127.6, ENSMUST00000000127.6
      Conserved Domains (1) summary
      cd19335
      Location:42355
      Wnt_Wnt3_Wnt3a; Wnt domain found in proto-oncogene Wnt-3 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      103665000..103708854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533168.1XP_006533231.1  proto-oncogene Wnt-3 isoform X1

      Conserved Domains (1) summary
      cl38924
      Location:2250
      Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family