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    NMD3 NMD3 ribosome export adaptor [ Homo sapiens (human) ]

    Gene ID: 51068, updated on 3-Dec-2024

    Summary

    Official Symbol
    NMD3provided by HGNC
    Official Full Name
    NMD3 ribosome export adaptorprovided by HGNC
    Primary source
    HGNC:HGNC:24250
    See related
    Ensembl:ENSG00000169251 MIM:611021; AllianceGenome:HGNC:24250
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CGI-07
    Summary
    Ribosomal 40S and 60S subunits associate in the nucleolus and are exported to the cytoplasm. The protein encoded by this gene is involved in the passage of the 60S subunit through the nuclear pore complex and into the cytoplasm. Several transcript variants exist for this gene, but the full-length natures of only two have been described to date. [provided by RefSeq, Feb 2016]
    Expression
    Ubiquitous expression in bone marrow (RPKM 18.0), urinary bladder (RPKM 15.3) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See NMD3 in Genome Data Viewer
    Location:
    3q26.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (161221102..161253532)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (163995873..164028302)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (160939099..160971320)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene beta-1,3-N-acetylgalactosaminyltransferase 1 (Globoside blood group) Neighboring gene uncharacterized LOC124909453 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14863 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14864 Neighboring gene uncharacterized LOC124906300 Neighboring gene uncharacterized LOC105374186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20768 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:160938841-160939342 Neighboring gene SRP14 pseudogene 5 Neighboring gene MPRA-validated peak4894 silencer Neighboring gene MPRA-validated peak4895 silencer Neighboring gene uncharacterized LOC105374187 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20769 Neighboring gene uncharacterized LOC112268450

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ21053

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ribosomal large subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ribosomal large subunit binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ribosomal large subunit binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane HDA PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    60S ribosomal export protein NMD3
    Names
    NMD3 homolog
    hNMD3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047147.1 RefSeqGene

      Range
      5050..36046
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001320227.2NP_001307156.1  60S ribosomal export protein NMD3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC108738, AK225664, DB480542
      Consensus CDS
      CCDS82870.1
      UniProtKB/TrEMBL
      B3KT11, C9JA08
      Related
      ENSP00000417559.1, ENST00000472947.5
      Conserved Domains (3) summary
      COG1499
      Location:9388
      NMD3; NMD protein affecting ribosome stability and mRNA decay [Translation, ribosomal structure and biogenesis]
      pfam04981
      Location:17246
      NMD3; NMD3 family
      cl00266
      Location:379521
      HGTP_anticodon; HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for ...
    2. NM_015938.5NP_057022.2  60S ribosomal export protein NMD3 isoform 2

      See identical proteins and their annotated locations for NP_057022.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC108738, BC013317
      Consensus CDS
      CCDS3194.1
      UniProtKB/Swiss-Prot
      D3DNM7, Q96D46, Q9Y2Z6
      UniProtKB/TrEMBL
      B3KT11
      Related
      ENSP00000307525.2, ENST00000351193.7
      Conserved Domains (1) summary
      pfam04981
      Location:17246
      NMD3; NMD3 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      161221102..161253532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005247511.3XP_005247568.1  60S ribosomal export protein NMD3 isoform X1

      See identical proteins and their annotated locations for XP_005247568.1

      UniProtKB/Swiss-Prot
      D3DNM7, Q96D46, Q9Y2Z6
      UniProtKB/TrEMBL
      B3KT11
      Conserved Domains (1) summary
      pfam04981
      Location:17246
      NMD3; NMD3 family
    2. XM_005247512.2XP_005247569.1  60S ribosomal export protein NMD3 isoform X1

      See identical proteins and their annotated locations for XP_005247569.1

      UniProtKB/Swiss-Prot
      D3DNM7, Q96D46, Q9Y2Z6
      UniProtKB/TrEMBL
      B3KT11
      Related
      ENSP00000419004.1, ENST00000460469.1
      Conserved Domains (1) summary
      pfam04981
      Location:17246
      NMD3; NMD3 family

    RNA

    1. XR_007095682.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      163995873..164028302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346715.1XP_054202690.1  60S ribosomal export protein NMD3 isoform X1

      UniProtKB/Swiss-Prot
      D3DNM7, Q96D46, Q9Y2Z6
      UniProtKB/TrEMBL
      B3KT11
    2. XM_054346716.1XP_054202691.1  60S ribosomal export protein NMD3 isoform X1

      UniProtKB/Swiss-Prot
      D3DNM7, Q96D46, Q9Y2Z6
      UniProtKB/TrEMBL
      B3KT11

    RNA

    1. XR_008486719.1 RNA Sequence