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    SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 [ Homo sapiens (human) ]

    Gene ID: 23583, updated on 12-Dec-2024

    Summary

    Official Symbol
    SMUG1provided by HGNC
    Official Full Name
    single-strand-selective monofunctional uracil-DNA glycosylase 1provided by HGNC
    Primary source
    HGNC:HGNC:17148
    See related
    Ensembl:ENSG00000123415 MIM:607753; AllianceGenome:HGNC:17148
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FDG; UNG3; HMUDG
    Summary
    This gene encodes a protein that participates in base excision repair by removing uracil from single- and double-stranded DNA. Many alternatively spliced transcript variants exist for this gene; the full-length nature is known for some but not all of the variants. [provided by RefSeq, Aug 2011]
    Expression
    Ubiquitous expression in skin (RPKM 3.7), placenta (RPKM 3.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SMUG1 in Genome Data Viewer
    Location:
    12q13.13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (54158235..54188985, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (54119277..54154492, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (54574150..54582769, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:54520229-54520862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:54520863-54521498 Neighboring gene family with sequence similarity 242 member C Neighboring gene long intergenic non-protein coding RNA 2381 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:54526452-54527376 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:54528656-54528824 Neighboring gene SMUG1 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 1237 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:54556725-54557225 Neighboring gene uncharacterized LOC102724030 Neighboring gene uncharacterized LOC105369777 Neighboring gene Sharpr-MPRA regulatory region 1888 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:54609784-54609969 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4524 Neighboring gene microRNA 3198-2 Neighboring gene chromobox 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr-induced reduction in single-strand selective monofunctional uracil DNA glycosylase (SMUG1) is mediated through proteasomal degradation PubMed
    vpr The interaction of Vpr with DDB1 facilitates the formation of complexes containing Cul4A-Roc1 E3 ubiquitin ligase. The association of Vpr with DDB1-containing E3 ligase mediates the degradation of UNG2 and SMUG1 PubMed
    vpr HIV-1 Vpr induces the ubiquitination of SMUG1 and forms a complex with SMUG1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC104370

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA N-glycosylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables single-strand selective uracil DNA N-glycosylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables single-strand selective uracil DNA N-glycosylase activity TAS
    Traceable Author Statement
    more info
     
    enables uracil DNA N-glycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables uracil DNA N-glycosylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in base-excision repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in depyrimidination TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    single-strand selective monofunctional uracil DNA glycosylase

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047137.2 RefSeqGene

      Range
      5000..13619
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001243787.2NP_001230716.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

      See identical proteins and their annotated locations for NP_001230716.1

      Status: REVIEWED

      Source sequence(s)
      AC023794, AI002776, AK222473, BG706635, CD245413
      Consensus CDS
      CCDS8874.1
      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
      Related
      ENSP00000507590.1, ENST00000682136.1
      Conserved Domains (1) summary
      cd19374
      Location:29258
      UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
    2. NM_001243788.2NP_001230717.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

      See identical proteins and their annotated locations for NP_001230717.1

      Status: REVIEWED

      Source sequence(s)
      AC023794, AI002776, DA430734
      Consensus CDS
      CCDS8874.1
      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
      Related
      ENSP00000424191.1, ENST00000508394.6
      Conserved Domains (1) summary
      cd19374
      Location:29258
      UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
    3. NM_001243789.2NP_001230718.1  single-strand selective monofunctional uracil DNA glycosylase isoform 2

      See identical proteins and their annotated locations for NP_001230718.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, 3' UTR, and coding region compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Variants 4-11 all encode the same isoform (2).
      Source sequence(s)
      AC023794, BC000417, BC088352, BG764502, DA703553
      Consensus CDS
      CCDS58239.1
      UniProtKB/TrEMBL
      A0A0S2Z526
      Related
      ENSP00000423629.1, ENST00000513838.5
      Conserved Domains (1) summary
      cl00483
      Location:29135
      UDG_like; Uracil-DNA glycosylases (UDG) and related enzymes
    4. NM_001243790.2NP_001230719.1  single-strand selective monofunctional uracil DNA glycosylase isoform 2

      See identical proteins and their annotated locations for NP_001230719.1

      Status: REVIEWED

      Source sequence(s)
      AC023794, BC088352, BG764502, DA703553
      Consensus CDS
      CCDS58239.1
      UniProtKB/TrEMBL
      A0A0S2Z526
      Related
      ENSP00000421139.1, ENST00000514685.5
      Conserved Domains (1) summary
      cl00483
      Location:29135
      UDG_like; Uracil-DNA glycosylases (UDG) and related enzymes
    5. NM_001243791.2NP_001230720.1  single-strand selective monofunctional uracil DNA glycosylase isoform 2

      See identical proteins and their annotated locations for NP_001230720.1

      Status: REVIEWED

      Source sequence(s)
      AC023794, BC088352, BC105607, BG706635
      Consensus CDS
      CCDS58239.1
      UniProtKB/TrEMBL
      A0A0S2Z526
      Related
      ENSP00000243112.5, ENST00000243112.9
      Conserved Domains (1) summary
      cl00483
      Location:29135
      UDG_like; Uracil-DNA glycosylases (UDG) and related enzymes
    6. NM_001351237.2NP_001338166.1  single-strand selective monofunctional uracil DNA glycosylase isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC023794
      Consensus CDS
      CCDS58239.1
      UniProtKB/TrEMBL
      A0A0S2Z526
      Related
      ENSP00000421206.1, ENST00000506595.5
      Conserved Domains (1) summary
      cl00483
      Location:29135
      UDG_like; Uracil-DNA glycosylases (UDG) and related enzymes
    7. NM_001351238.2NP_001338167.1  single-strand selective monofunctional uracil DNA glycosylase isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC023794
      Consensus CDS
      CCDS58239.1
      UniProtKB/TrEMBL
      A0A0S2Z526
      Conserved Domains (1) summary
      cl00483
      Location:29135
      UDG_like; Uracil-DNA glycosylases (UDG) and related enzymes
    8. NM_001351239.2NP_001338168.1  single-strand selective monofunctional uracil DNA glycosylase isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC023794
      Consensus CDS
      CCDS58239.1
      UniProtKB/TrEMBL
      A0A0S2Z526
      Conserved Domains (1) summary
      cl00483
      Location:29135
      UDG_like; Uracil-DNA glycosylases (UDG) and related enzymes
    9. NM_001351240.2NP_001338169.1  single-strand selective monofunctional uracil DNA glycosylase isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC023794
      Consensus CDS
      CCDS58239.1
      UniProtKB/TrEMBL
      A0A0S2Z526
      Conserved Domains (1) summary
      cl00483
      Location:29135
      UDG_like; Uracil-DNA glycosylases (UDG) and related enzymes
    10. NM_001351241.2NP_001338170.1  single-strand selective monofunctional uracil DNA glycosylase isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC023794
      Consensus CDS
      CCDS58239.1
      UniProtKB/TrEMBL
      A0A0S2Z526
      Conserved Domains (1) summary
      cl00483
      Location:29135
      UDG_like; Uracil-DNA glycosylases (UDG) and related enzymes
    11. NM_001351242.2NP_001338171.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC023794
      Consensus CDS
      CCDS8874.1
      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
      Conserved Domains (1) summary
      cd19374
      Location:29258
      UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
    12. NM_001351243.2NP_001338172.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC023794
      Consensus CDS
      CCDS8874.1
      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
      Conserved Domains (1) summary
      cd19374
      Location:29258
      UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
    13. NM_001351244.2NP_001338173.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC023794
      Consensus CDS
      CCDS8874.1
      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
      Conserved Domains (1) summary
      cd19374
      Location:29258
      UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
    14. NM_001351245.2NP_001338174.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC023794
      Consensus CDS
      CCDS8874.1
      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
      Conserved Domains (1) summary
      cd19374
      Location:29258
      UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
    15. NM_001351246.2NP_001338175.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC023794
      Consensus CDS
      CCDS8874.1
      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
      Conserved Domains (1) summary
      cd19374
      Location:29258
      UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
    16. NM_001351247.2NP_001338176.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC023794
      Consensus CDS
      CCDS8874.1
      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
      Conserved Domains (1) summary
      cd19374
      Location:29258
      UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
    17. NM_001351248.2NP_001338177.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC023794
      Consensus CDS
      CCDS8874.1
      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
      Conserved Domains (1) summary
      cd19374
      Location:29258
      UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
    18. NM_001351249.2NP_001338178.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC023794
      Consensus CDS
      CCDS8874.1
      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
      Conserved Domains (1) summary
      cd19374
      Location:29258
      UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
    19. NM_001351250.2NP_001338179.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC023794
      Consensus CDS
      CCDS8874.1
      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
      Conserved Domains (1) summary
      cd19374
      Location:29258
      UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
    20. NM_001351251.2NP_001338180.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC023794
      Consensus CDS
      CCDS8874.1
      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
      Conserved Domains (1) summary
      cd19374
      Location:29258
      UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
    21. NM_001351252.2NP_001338181.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC023794
      Consensus CDS
      CCDS8874.1
      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
      Conserved Domains (1) summary
      cd19374
      Location:29258
      UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
    22. NM_001351253.2NP_001338182.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC023794
      Consensus CDS
      CCDS8874.1
      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
      Conserved Domains (1) summary
      cd19374
      Location:29258
      UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
    23. NM_001351254.2NP_001338183.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC023794
      Consensus CDS
      CCDS8874.1
      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
      Conserved Domains (1) summary
      cd19374
      Location:29258
      UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
    24. NM_001351255.2NP_001338184.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC023794
      Consensus CDS
      CCDS8874.1
      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
      Conserved Domains (1) summary
      cd19374
      Location:29258
      UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
    25. NM_001351256.2NP_001338185.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC023794
      Consensus CDS
      CCDS8874.1
      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
      Conserved Domains (1) summary
      cd19374
      Location:29258
      UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
    26. NM_001351257.2NP_001338186.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC023794
      Consensus CDS
      CCDS8874.1
      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
      Conserved Domains (1) summary
      cd19374
      Location:29258
      UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
    27. NM_001351258.2NP_001338187.1  single-strand selective monofunctional uracil DNA glycosylase isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC023794
      Conserved Domains (1) summary
      cl00483
      Location:29201
      UDG_like; Uracil-DNA glycosylases (UDG) and related enzymes
    28. NM_001351259.2NP_001338188.1  single-strand selective monofunctional uracil DNA glycosylase isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (29) encodes isoform (4). Variants 29 and 30 both encode the same isoform (4).
      Source sequence(s)
      AC023794
      Conserved Domains (1) summary
      cl00483
      Location:1156
      UDG-like; uracil-DNA glycosylases (UDG) and related enzymes
    29. NM_001351260.2NP_001338189.1  single-strand selective monofunctional uracil DNA glycosylase isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC023794
      Conserved Domains (1) summary
      cl00483
      Location:1156
      UDG-like; uracil-DNA glycosylases (UDG) and related enzymes
    30. NM_001351261.2NP_001338190.1  single-strand selective monofunctional uracil DNA glycosylase isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC023794
      Consensus CDS
      CCDS86305.1
      UniProtKB/TrEMBL
      D6RI04, H0YA95
      Related
      ENSP00000425974.1, ENST00000514196.5
      Conserved Domains (2) summary
      cd09593
      Location:8387
      UDG-like; motif A [structural motif]
      cl00483
      Location:29135
      UDG-like; uracil-DNA glycosylases (UDG) and related enzymes
    31. NM_001351262.2NP_001338191.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC023794
      Consensus CDS
      CCDS8874.1
      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
      Related
      ENSP00000384828.2, ENST00000401977.6
      Conserved Domains (1) summary
      cd19374
      Location:29258
      UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
    32. NM_014311.3NP_055126.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

      See identical proteins and their annotated locations for NP_055126.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1-3, 12-27, and 32 all encode the same isoform (1).
      Source sequence(s)
      AC023794, AI002776, AK001235, BG706635
      Consensus CDS
      CCDS8874.1
      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
      Related
      ENSP00000338606.3, ENST00000337581.7
      Conserved Domains (1) summary
      cd19374
      Location:29258
      UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      54158235..54188985 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428642.1XP_047284598.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
    2. XM_047428640.1XP_047284596.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
    3. XM_047428654.1XP_047284610.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z526
    4. XM_006719319.4XP_006719382.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      See identical proteins and their annotated locations for XP_006719382.1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
      Conserved Domains (1) summary
      cd19374
      Location:29258
      UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
    5. XM_047428653.1XP_047284609.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z526
    6. XM_047428650.1XP_047284606.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z526
    7. XM_011538119.3XP_011536421.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      See identical proteins and their annotated locations for XP_011536421.1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
      Conserved Domains (1) summary
      cd19374
      Location:29258
      UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
    8. XM_011538121.3XP_011536423.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      See identical proteins and their annotated locations for XP_011536423.1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
      Conserved Domains (1) summary
      cd19374
      Location:29258
      UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
    9. XM_047428649.1XP_047284605.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z526
    10. XM_047428655.1XP_047284611.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z526
    11. XM_047428641.1XP_047284597.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
    12. XM_011538116.3XP_011536418.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      See identical proteins and their annotated locations for XP_011536418.1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
      Conserved Domains (1) summary
      cd19374
      Location:29258
      UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
    13. XM_047428648.1XP_047284604.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z526
    14. XM_047428646.1XP_047284602.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z526
    15. XM_047428644.1XP_047284600.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z526
    16. XM_047428645.1XP_047284601.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z526
    17. XM_047428633.1XP_047284589.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
    18. XM_047428636.1XP_047284592.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
    19. XM_011538112.3XP_011536414.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      See identical proteins and their annotated locations for XP_011536414.1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
      Conserved Domains (1) summary
      cd19374
      Location:29258
      UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
    20. XM_047428635.1XP_047284591.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
    21. XM_011538118.3XP_011536420.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      See identical proteins and their annotated locations for XP_011536420.1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
      Conserved Domains (1) summary
      cd19374
      Location:29258
      UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
    22. XM_047428643.1XP_047284599.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z526
    23. XM_047428634.1XP_047284590.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
    24. XM_047428652.1XP_047284608.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z526
    25. XM_047428638.1XP_047284594.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
    26. XM_047428651.1XP_047284607.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z526
    27. XM_047428632.1XP_047284588.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
    28. XM_047428639.1XP_047284595.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
    29. XM_047428637.1XP_047284593.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8

    RNA

    1. XR_007063064.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      54119277..54154492 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054371632.1XP_054227607.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
    2. XM_054371631.1XP_054227606.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
    3. XM_054371641.1XP_054227616.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z526
    4. XM_054371630.1XP_054227605.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
    5. XM_054371640.1XP_054227615.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z526
    6. XM_054371645.1XP_054227620.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z526
    7. XM_054371624.1XP_054227599.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
    8. XM_054371636.1XP_054227611.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
    9. XM_054371646.1XP_054227621.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z526
    10. XM_054371648.1XP_054227623.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z526
    11. XM_054371635.1XP_054227610.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
    12. XM_054371633.1XP_054227608.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
    13. XM_054371638.1XP_054227613.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z526
    14. XM_054371644.1XP_054227619.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z526
    15. XM_054371643.1XP_054227618.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z526
    16. XM_054371642.1XP_054227617.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z526
    17. XM_054371625.1XP_054227600.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
    18. XM_054371626.1XP_054227601.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
    19. XM_054371620.1XP_054227595.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
    20. XM_054371634.1XP_054227609.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
    21. XM_054371623.1XP_054227598.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
    22. XM_054371637.1XP_054227612.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z526
    23. XM_054371621.1XP_054227596.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
    24. XM_054371639.1XP_054227614.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z526
    25. XM_054371628.1XP_054227603.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
    26. XM_054371647.1XP_054227622.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z526
    27. XM_054371622.1XP_054227597.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
    28. XM_054371629.1XP_054227604.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8
    29. XM_054371627.1XP_054227602.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
      UniProtKB/TrEMBL
      A0A024RAZ8

    RNA

    1. XR_008488560.1 RNA Sequence