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    Itgb7 integrin subunit beta 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25713, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Itgb7provided by RGD
    Official Full Name
    integrin subunit beta 7provided by RGD
    Primary source
    RGD:2929
    See related
    EnsemblRapid:ENSRNOG00000012208 AllianceGenome:RGD:2929
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable integrin binding activity. Predicted to be involved in several processes, including integrin-mediated signaling pathway; leukocyte tethering or rolling; and substrate adhesion-dependent cell spreading. Predicted to act upstream of or within T cell migration. Predicted to be part of integrin alpha4-beta7 complex. Predicted to be active in cell surface and focal adhesion. Orthologous to human ITGB7 (integrin subunit beta 7). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Thymus (RPKM 121.1), Spleen (RPKM 79.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Itgb7 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (135225962..135243522, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (133347927..133364955, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (143820236..143837802, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene sterol O-acyltransferase 2 Neighboring gene cysteine sulfinic acid decarboxylase Neighboring gene zinc finger protein 740 Neighboring gene uncharacterized LOC134479582 Neighboring gene retinoic acid receptor, gamma Neighboring gene uncharacterized LOC134479581

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Integrin αEβ7 is involved in the intestinal barrier injury of sepsis. Sun JK, et al. Aging (Albany NY), 2022 Jan 18. PMID 35042191, Free PMC Article
    2. Structure-function analysis of the integrin beta 7 subunit: identification of domains involved in adhesion to MAdCAM-1. Tidswell M, et al. J Immunol, 1997 Aug 1. PMID 9233649
    3. Disruption of disulfide restriction at integrin knees induces activation and ligand-independent signaling of α₄β₇. Zhang K, et al. J Cell Sci, 2013 Nov 1. PMID 23986478
    4. Functional involvement of P-selectin and MAdCAM-1 in the recruitment of alpha4beta7-integrin-expressing monocyte-like cells to the pregnant mouse uterus. Fernekorn U, et al. Eur J Immunol, 2004 Dec. PMID 15484189
    5. GPR15-mediated homing controls immune homeostasis in the large intestine mucosa. Kim SV, et al. Science, 2013 Jun 21. PMID 23661644, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Integrin alphaEbeta7 is involved in the intestinal barrier injury of sepsis.
      Title: Integrin αEβ7 is involved in the intestinal barrier injury of sepsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell-matrix adhesion involved in ameboidal cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukocyte migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within leukocyte migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukocyte tethering or rolling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in receptor clustering ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrin alpha4-beta7 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of integrin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    integrin beta-7
    Names
    integrin, beta 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013171.1 → NP_037303.1  integrin beta-7 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6KCT9, G3V7M2
      Conserved Domains (5) summary
      pfam00362
      Location:50 → 477
      Integrin_beta; Integrin, beta chain
      pfam07965
      Location:646 → 717
      Integrin_B_tail; Integrin beta tail domain
      pfam07974
      Location:608 → 636
      EGF_2; EGF-like domain
      pfam08725
      Location:750 → 791
      Integrin_b_cyt; Integrin beta cytoplasmic domain
      pfam12785
      Location:538 → 646
      VESA1_N; Variant erythrocyte surface antigen-1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      135225962..135243522 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242383.5 → XP_006242445.1  integrin beta-7 isoform X1

      UniProtKB/TrEMBL
      A6KCT9, G3V7M2
      Related
      ENSRNOP00000016642.4, ENSRNOT00000016642.8
      Conserved Domains (5) summary
      pfam00362
      Location:50 → 477
      Integrin_beta; Integrin, beta chain
      pfam07965
      Location:646 → 717
      Integrin_B_tail; Integrin beta tail domain
      pfam07974
      Location:608 → 636
      EGF_2; EGF-like domain
      pfam08725
      Location:750 → 791
      Integrin_b_cyt; Integrin beta cytoplasmic domain
      pfam12785
      Location:538 → 646
      VESA1_N; Variant erythrocyte surface antigen-1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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