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    l(2)34Fd lethal (2) 34Fd [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34839, updated on 9-Dec-2024

    Summary

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    Official Symbol
    l(2)34Fdprovided by FlyBase
    Official Full Name
    lethal (2) 34Fdprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261535
    Locus tag
    Dmel_CG7516
    See related
    AllianceGenome:FB:FBgn0261535
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    A4; BG:DS01068.6; br15; CG7516; Dmel\CG7516; l(2)br15
    Summary
    Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleus. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; and mesoderm. Orthologous to human NOL10 (nucleolar protein 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See l(2)34Fd in Genome Data Viewer
    Location:
    35A4-35A4; 2-50 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (14352594..14355085, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (14352594..14355085, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene mitochondrial transcription termination factor Neighboring gene antisense RNA:CR44850 Neighboring gene lethal (2) 34Fc Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44851 Neighboring gene Rab14 Neighboring gene antisense RNA:CR43463 Neighboring gene Polypeptide N-acetylgalactosaminyltransferase 35A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The molecular analysis of the el-noc complex of Drosophila melanogaster. Davis T, et al. Genetics, 1990 Sep. PMID 2121591, Free PMC Article
    2. Developmental timing of a sensory-mediated larval surfacing behavior correlates with cessation of feeding and determination of final adult size. Wegman LJ, et al. Dev Biol, 2010 Sep 15. PMID 20630480, Free PMC Article
    3. The genetics of a small chromosome region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. IV: scutoid, an antimorphic mutation. Ashburner M, et al. Genetics, 1982 Nov. PMID 6816673, Free PMC Article
    4. Genetic and cytogenetic analysis of the Adh region in Drosophila melanogaster. O'Donnell J, et al. Genetics, 1977 Jul. PMID 408228, Free PMC Article
    5. A novel transvection phenomenon affecting the white gene of Drosophila melanogaster. Gubb D, et al. Genetics, 1990 Sep. PMID 2121594, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lethal (2) 34Fd
    Names
    CG7516-PA
    l(2)34Fd-PA
    lethal 15 in the black-reduced region
    lethal group A4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      14352594..14355085 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135867.4 → NP_609711.1  lethal (2) 34Fd [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609711.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3P2
      Related
      FBpp0080211
      Conserved Domains (5) summary
      COG2319
      Location:38 → 338
      WD40; WD40 repeat [General function prediction only]
      pfam04514
      Location:396 → 584
      BTV_NS2; Bluetongue virus non-structural protein NS2
      pfam08159
      Location:476 → 503
      NUC153; NUC153 domain
      sd00039
      Location:179 → 215
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:149 → 329
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3P2 Q9V3P2

    Gene LinkOut

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