PEN2 Glycosyl hydrolase superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PEN2
Official Full Name: Glycosyl hydrolase superfamily protein
Primary source: TAIR:AT2G44490
Locus tag: AT2G44490
See related: Araport:AT2G44490
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: BETA GLUCOSIDASE 26; BGLU26; F4I1.30; PENETRATION 2
Summary: Encodes a glycosyl hydrolase that localizes to peroxisomes and acts as a component of an inducible preinvasion resistance mechanism. Required for mlo resistance.
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Genomic context

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See PEN2 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 11

Sequence:: Chromosome: 2; NC_003071.7 (18364652..18367835)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PEN2 is a tail-anchored protein with dual-membrane targeting to peroxisomes and mitochondria and that PEN2 has the capacity to form homo-oligomer complexes.
Title: Immobilized Subpopulations of Leaf Epidermal Mitochondria Mediate PENETRATION2-Dependent Pathogen Entry Control in Arabidopsis.
COR suppresses an salicylic acid (SA)-independent pathway contributing to callose deposition by reducing accumulation of an indole glucosinolate upstream of the activity of the PEN2 myrosinase.
Title: The coronatine toxin of Pseudomonas syringae is a multifunctional suppressor of Arabidopsis defense.
Double mutant analysis indicated that AGB1 and PMR5 contribute to PEN2-mediated preinvasion resistance to M. oryzae in A. thaliana, suggesting a complex genetic network regulating the resistance.
Title: AGB1 and PMR5 contribute to PEN2-mediated preinvasion resistance to Magnaporthe oryzae in Arabidopsis thaliana.
CYP81F2 gene encodes a P450 monooxygenase that is essential for the pathogen-induced accumulation of 4-methoxyindol-3-ylmethylglucosinolate, which in turn is activated by the atypical PEN2 myrosinase for antifungal defense
Title: A glucosinolate metabolism pathway in living plant cells mediates broad-spectrum antifungal defense.
PEN2 restricts pathogen entry of two ascomycete powdery mildew fungi that in nature colonize grass and pea species; the PEN2 glycosyl hydrolase localizes to peroxisomes and acts as a component of an inducible preinvasion resistance mechanism. [PEN2]
Title: Pre- and postinvasion defenses both contribute to nonhost resistance in Arabidopsis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_130012.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables beta-glucosidase activity	IEA Inferred from Electronic Annotation more info
enables thioglucosidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response by callose deposition in cell wall	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glucosinolate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within indole glucosinolate catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within induced systemic resistance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast envelope	HDA more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Glycosyl hydrolase superfamily protein

NP_181977.1

PENETRATION 2 (PEN2); FUNCTIONS IN: thioglucosidase activity, hydrolase activity, hydrolyzing O-glycosyl compounds; INVOLVED IN: defense response to fungus, incompatible interaction, glucosinolate metabolic process, defense response to bacterium, indole glucosinolate catabolic process, defense response by callose deposition in cell wall; LOCATED IN: peroxisome, membrane, chloroplast envelope; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Glycoside hydrolase, family 1 (InterPro:IPR001360), Glycoside hydrolase, family 1, active site (InterPro:IPR018120), Glycoside hydrolase, catalytic core (InterPro:IPR017853), Glycoside hydrolase, subgroup, catalytic core (InterPro:IPR013781); BEST Arabidopsis thaliana protein match is: beta glucosidase 27 (TAIR:AT3G60120.1); Has 11449 Blast hits to 11083 proteins in 1474 species: Archae - 140; Bacteria - 7930; Metazoa - 713; Fungi - 202; Plants - 1462; Viruses - 0; Other Eukaryotes - 1002 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

18364652..18367835

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_130012.4 → NP_181977.1 Glycosyl hydrolase superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_181977.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O64883

UniProtKB/TrEMBL

A0A178VUB6, A0A5S9X6Y3, A0A654F728

Conserved Domains (1) summary

cl23725
Location:16 → 493

Glyco_hydro; Glycosyl hydrolases