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    RhoGAP19D Rho GTPase activating protein at 19D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33048, updated on 27-Dec-2024

    Summary

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    Official Symbol
    RhoGAP19Dprovided by FlyBase
    Official Full Name
    Rho GTPase activating protein at 19Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031118
    Locus tag
    Dmel_CG1412
    See related
    AllianceGenome:FB:FBgn0031118
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1412; CG1412; Dmel\CG1412
    Summary
    Predicted to enable GTPase activator activity. Involved in imaginal disc-derived leg morphogenesis. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including embryonic/larval posterior spiracle; fat body/gonad primordium; longitudinal trunk visceral muscle primordium; longitudinal visceral muscle fiber; and trunk mesoderm. Orthologous to several human genes including ARHGAP23 (Rho GTPase activating protein 23). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RhoGAP19D in Genome Data Viewer
    Location:
    19D1-19D2; 1-64 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (20469955..20510694, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20340982..20381721, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene trabuco Neighboring gene Glutathione S transferase T3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene TGF-beta activated kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mind bomb 2 promotes cell migration and epithelial structure by regulating adhesion complexes and the actin cytoskeleton. Trivedi S, et al. Dev Biol, 2022 Nov. PMID 36067835
    2. The elmo-mbc complex and rhogap19d couple Rho family GTPases during mesenchymal-to-epithelial-like transitions. Toret CP, et al. Development, 2018 Feb 2. PMID 29437779
    3. An Orthologous Epigenetic Gene Expression Signature Derived from Differentiating Embryonic Stem Cells Identifies Regulators of Cardiogenesis. Busser BW, et al. PLoS One, 2015. PMID 26485529, Free PMC Article
    4. Inference of RhoGAP/GTPase regulation using single-cell morphological data from a combinatorial RNAi screen. Nir O, et al. Genome Res, 2010 Mar. PMID 20144944, Free PMC Article
    5. Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion. Hu H, et al. Proc Natl Acad Sci U S A, 2005 Mar 22. PMID 15755809, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RhoGAP19D inhibits Cdc42 laterally to control epithelial cell shape and prevent invasion.
      Title: RhoGAP19D inhibits Cdc42 laterally to control epithelial cell shape and prevent invasion.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c20481247-20480940 mobile_element_type = transposon:INE-1{}5415

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in imaginal disc-derived leg morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rho GTPase activating protein at 19D
    Names
    CG1412-PA
    CG1412-PB
    CG1412-PC
    CG1412-PD
    CG1412-PE
    RhoGAP19D-PA
    RhoGAP19D-PB
    RhoGAP19D-PC
    RhoGAP19D-PD
    RhoGAP19D-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      20469955..20510694 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169338.2 → NP_001162809.1  Rho GTPase activating protein at 19D, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162809.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJS2, Q6IDH3
      Conserved Domains (2) summary
      cd00992
      Location:151 → 205
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:1195 → 1391
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...

    2. NM_001258851.1 → NP_001245780.1  Rho GTPase activating protein at 19D, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245780.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NFH4, Q6IDH3
      Conserved Domains (2) summary
      cd00992
      Location:151 → 205
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:1221 → 1417
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...

    3. NM_001298567.1 → NP_001285496.1  Rho GTPase activating protein at 19D, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285496.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6IDH3, X2JEI9
      Conserved Domains (2) summary
      cd00992
      Location:151 → 205
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:1221 → 1417
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...

    4. NM_001298568.1 → NP_001285497.1  Rho GTPase activating protein at 19D, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285497.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NFH4, Q6IDH3
      Conserved Domains (2) summary
      cd00992
      Location:151 → 205
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:1221 → 1417
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...

    5. NM_134552.6 → NP_608396.2  Rho GTPase activating protein at 19D, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608396.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6IDH3, Q9VRA6
      Related
      FBpp0077012
      Conserved Domains (2) summary
      cd00992
      Location:151 → 205
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:1196 → 1392
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JJS2 E1JJS2
    M9NFH4 M9NFH4
    Q95TR0 Q95TR0
    Q9VRA6 Q9VRA6
    X2JEI9 X2JEI9

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