myo myoglianin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: myoprovided by FlyBase
Official Full Name: myoglianinprovided by FlyBase
Primary source: FLYBASE:FBgn0026199
Locus tag: Dmel_CG1838
See related: AllianceGenome:FB:FBgn0026199
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:LD02307; CG1838; Dmel\CG1838; DmMyo; myg; Myo; MYO; Myoglianin
Summary: Enables activin receptor binding activity and receptor ligand activity. Involved in several processes, including activin receptor signaling pathway; nervous system development; and positive regulation of SMAD protein signal transduction. Acts upstream of with a positive effect on determination of adult lifespan. Located in nucleus. Is expressed in several structures, including glial cell; heart primordium; larval muscle cell; pole plasm; and primordial germ cell. Used to study vertebral hypersegmentation and orofacial anomalies. Human ortholog(s) of this gene implicated in myostatin-related muscle hypertrophy and vertebral hypersegmentation and orofacial anomalies. Orthologous to human GDF11 (growth differentiation factor 11) and MSTN (myostatin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	4	NC_004353.4 (690686..696055, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	4	NC_004353.3 (711312..716681, complement)

Chromosome 4 - NC_004353.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables activin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in R8 cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in activin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in activin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of SMAD protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of imaginal disc-derived wing size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse structure or activity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed

Names: CG1838-PA; CG1838-PC; CG1838-PD; DmMyoglianin; myo-PA; myo-PC; myo-PD; myoglianine

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