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    emb1997 para-aminobenzoate (PABA) synthase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817437, updated on 18-Sep-2024

    Summary

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    Official Symbol
    emb1997
    Official Full Name
    para-aminobenzoate (PABA) synthase family protein
    Primary source
    TAIR:AT2G28880
    Locus tag
    AT2G28880
    See related
    Araport:AT2G28880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ADCS; aminodeoxychorismate synthase; Aminodeoxychorismate synthase; embryo defective 1997; F8N16.17; F8N16_17
    Summary
    ADCS encodes a protein that has two functional domains. The N-terminal domain has glutamine amidotransferase activity while the C-terminal domain has aminodeoxychorismate synthase (ADCS) activity. These two domains act together to catalyze the transformation of chorismate to 4-amino-4-deoxychorismate. This reaction is required for 4-aminobenzoate (pABA) production and ultimately for folate biosynthesis. The putative target peptide of ADCS can direct GFP to the chloroplast.
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    Genomic context

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    See emb1997 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    14
    Sequence:
    Chromosome: 2; NC_003071.7 (12398745..12403621, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene cyclin-dependent kinase inhibitor SMR1-like protein Neighboring gene poltergeist like 4 Neighboring gene outer plastid envelope protein 16-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The synthesis of pABA: Coupling between the glutamine amidotransferase and aminodeoxychorismate synthase domains of the bifunctional aminodeoxychorismate synthase from Arabidopsis thaliana. Camara D, et al. Arch Biochem Biophys, 2011 Jan 1. PMID 20851095
    2. Rice folate enhancement through metabolic engineering has an impact on rice seed metabolism, but does not affect the expression of the endogenous folate biosynthesis genes. Blancquaert D, et al. Plant Mol Biol, 2013 Nov. PMID 23771598
    3. Folate synthesis in plants: the p-aminobenzoate branch is initiated by a bifunctional PabA-PabB protein that is targeted to plastids. Basset GJ, et al. Proc Natl Acad Sci U S A, 2004 Feb 10. PMID 14745019, Free PMC Article
    4. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
    5. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The expression of both At-GTPCHI and At-ADCS is concordant with the accumulation of folate and its precursors in the developing transgenic rice seeds.
      Title: Rice folate enhancement through metabolic engineering has an impact on rice seed metabolism, but does not affect the expression of the endogenous folate biosynthesis genes.
    2. In a stable recombinant glutamine amidotransferase (GAT) -minodeoxychorismate synthase (ADCS), the GAT activity was always higher than that of ADCS, the excess of NH(3) being released in the external medium. [ADCS]
      Title: The synthesis of pABA: Coupling between the glutamine amidotransferase and aminodeoxychorismate synthase domains of the bifunctional aminodeoxychorismate synthase from Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_179796.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 4-amino-4-deoxychorismate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chorismate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy NAS
    Non-traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within folic acid biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within para-aminobenzoic acid biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in tetrahydrofolate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    para-aminobenzoate (PABA) synthase family protein
    NP_850127.1
    • embryo defective 1997 (emb1997); FUNCTIONS IN: oxo-acid-lyase activity, catalytic activity, anthranilate synthase activity; INVOLVED IN: embryo development ending in seed dormancy; LOCATED IN: chloroplast; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Glutamine amidotransferase class-I, C-terminal (InterPro:IPR000991), Glutamine amidotransferase superfamily (InterPro:IPR011702), Anthranilate synthase, glutamine amidotransferase domain (InterPro:IPR006221), Carbamoyl phosphate synthase, GATase domain (InterPro:IPR001317), Anthranilate synthase component I, N-terminal (InterPro:IPR006805), Chorismate binding, C-terminal (InterPro:IPR015890), ADC synthase (InterPro:IPR005801), Para-aminobenzoate synthase, component I (InterPro:IPR005802), Glutamine amidotransferase type 1 (InterPro:IPR017926), Anthranilate synthase component II/delta crystallin (InterPro:IPR006220); BEST Arabidopsis thaliana protein match is: anthranilate synthase 2 (TAIR:AT2G29690.1); Has 26955 Blast hits to 26481 proteins in 3128 species: Archae - 525; Bacteria - 17829; Metazoa - 510; Fungi - 766; Plants - 261; Viruses - 0; Other Eukaryotes - 7064 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      12398745..12403621 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179796.2 → NP_850127.1  para-aminobenzoate (PABA) synthase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850127.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LPN3, Q9ZV26
      UniProtKB/TrEMBL
      A0A178VQ13, A0A5S9X2A7, A0A654EX35
      Conserved Domains (1) summary
      PLN02889
      Location:3 → 919
      PLN02889; oxo-acid-lyase/anthranilate synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LPN3.1

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