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    GlcNAc1pUT1 N-acetylglucosamine-1-phosphate uridylyltransferase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839993, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GlcNAc1pUT1
    Official Full Name
    N-acetylglucosamine-1-phosphate uridylyltransferase 1
    Primary source
    TAIR:AT1G31070
    Locus tag
    AT1G31070
    See related
    Araport:AT1G31070
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F17F8.1; GLCNA.UT1; N-acetylglucosamine-1-phosphate uridylyltransferase 1
    Summary
    Encodes a protein that functions as an N-acetylglucosamine-1-phosphate uridylyltransferase that catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc). This is an essential precursor for glycolipid and glycoprotein synthesis and is also used for regulatory protein modification in signaling pathways. The enzyme can also catalyze the reverse reaction using both UDP-GlcNAc and the less common UDP-N-acetylgalactosamine as substrates.
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    Genomic context

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    See GlcNAc1pUT1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    14
    Sequence:
    Chromosome: 1; NC_003070.9 (11084666..11088589)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene PLATZ transcription factor family protein Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene miscRNA Neighboring gene F-box family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. N-acetylglucosamine-1-P uridylyltransferase 1 and 2 are required for gametogenesis and embryo development in Arabidopsis thaliana. Chen YH, et al. Plant Cell Physiol, 2014 Nov. PMID 25231969
    2. Identification and characterization of a strict and a promiscuous N-acetylglucosamine-1-P uridylyltransferase in Arabidopsis. Yang T, et al. Biochem J, 2010 Sep 1. PMID 20557289
    3. A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome. Marmagne A, et al. Mol Cell Proteomics, 2007 Nov. PMID 17644812
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. At1g31070 is required for gametogenesis and embryo development in Arabidopsis thaliana.
      Title: N-acetylglucosamine-1-P uridylyltransferase 1 and 2 are required for gametogenesis and embryo development in Arabidopsis thaliana.
    2. AT1G31070 catalyses the formation of UDP-N-acetylglucosamine and PPi from the monosaccharide 1-phosphate and UTP.
      Title: Identification and characterization of a strict and a promiscuous N-acetylglucosamine-1-P uridylyltransferase in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_001332942.1
    NM_102845.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables UDP-N-acetylgalactosamine diphosphorylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-N-acetylglucosamine diphosphorylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables uridylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within UDP-N-acetylgalactosamine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in UDP-N-acetylglucosamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within UDP-N-acetylglucosamine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo sac development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    N-acetylglucosamine-1-phosphate uridylyltransferase 1
    NP_001319120.1
    • N-acetylglucosamine-1-phosphate uridylyltransferase 1 (GlcNAc1pUT1); FUNCTIONS IN: UDP-N-acetylglucosamine diphosphorylase activity, UDP-N-acetylgalactosamine diphosphorylase activity; INVOLVED IN: UDP-N-acetylglucosamine metabolic process, UDP-N-acetylgalactosamine metabolic process; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: UTP--glucose-1-phosphate uridylyltransferase (InterPro:IPR002618); BEST Arabidopsis thaliana protein match is: N-acetylglucosamine-1-phosphate uridylyltransferase 2 (TAIR:AT2G35020.1); Has 709 Blast hits to 709 proteins in 330 species: Archae - 0; Bacteria - 268; Metazoa - 183; Fungi - 149; Plants - 68; Viruses - 0; Other Eukaryotes - 41 (source: NCBI BLink).
    NP_564372.3
    • N-acetylglucosamine-1-phosphate uridylyltransferase 1 (GlcNAc1pUT1); FUNCTIONS IN: UDP-N-acetylglucosamine diphosphorylase activity, UDP-N-acetylgalactosamine diphosphorylase activity; INVOLVED IN: UDP-N-acetylglucosamine metabolic process, UDP-N-acetylgalactosamine metabolic process; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: UTP--glucose-1-phosphate uridylyltransferase (InterPro:IPR002618); BEST Arabidopsis thaliana protein match is: N-acetylglucosamine-1-phosphate uridylyltransferase 2 (TAIR:AT2G35020.1); Has 1399 Blast hits to 1393 proteins in 421 species: Archae - 0; Bacteria - 358; Metazoa - 399; Fungi - 277; Plants - 154; Viruses - 0; Other Eukaryotes - 211 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      11084666..11088589
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001332942.1 → NP_001319120.1  N-acetylglucosamine-1-phosphate uridylyltransferase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4I7V2

    2. NM_102845.5 → NP_564372.3  N-acetylglucosamine-1-phosphate uridylyltransferase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564372.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q940S3, Q9FYJ8
      UniProtKB/TrEMBL
      A0A178W850, A0A5S9WGE7
      Conserved Domains (1) summary
      PLN02435
      Location:1 → 505
      PLN02435; probable UDP-N-acetylglucosamine pyrophosphorylase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q940S3.1

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