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    HSK homoserine kinase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816232, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HSK
    Official Full Name
    homoserine kinase
    Primary source
    TAIR:AT2G17265
    Locus tag
    AT2G17265
    See related
    Araport:AT2G17265
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DMR1; DOWNY MILDEW RESISTANT 1; F5J6.24; F5J6_24; homoserine kinase; HOMOSERINE KINASE
    Summary
    Encodes a homoserine kinase (HSK) which produces O-phospho-L-homoserine (HserP), a compound at the branching point of methionine and threonine biosynthesis. HSK is found in the stromal fraction of chloroplasts. Mutation of this gene results in higher level of the amino acid homoserine and resistance to downy mildew pathogen Hyaloperonospora arabidopsidis.
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    Genomic context

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    See HSK in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    1
    Sequence:
    Chromosome: 2; NC_003071.7 (7508473..7509887)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene CCAAT-binding factor Neighboring gene glutamate receptor 2 Neighboring gene phosphate transporter 3;3 Neighboring gene Phosphoglycerate mutase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in the Arabidopsis homoserine kinase gene DMR1 confer enhanced resistance to Fusarium culmorum and F. graminearum. Brewer HC, et al. BMC Plant Biol, 2014 Nov 29. PMID 25432266, Free PMC Article
    2. Characterization of a novel developmentally retarded mutant (drm1) associated with the autonomous flowering pathway in Arabidopsis. Zhu Y, et al. Cell Res, 2005 Feb. PMID 15740643
    3. Methionine and threonine synthesis are limited by homoserine availability and not the activity of homoserine kinase in Arabidopsis thaliana. Lee M, et al. Plant J, 2005 Mar. PMID 15703056
    4. Identification of arabidopsis loci required for susceptibility to the downy mildew pathogen Hyaloperonospora parasitica. Van Damme M, et al. Mol Plant Microbe Interact, 2005 Jun. PMID 15986928
    5. Powdery mildew resistance in tomato by impairment of SlPMR4 and SlDMR1. Huibers RP, et al. PLoS One, 2013. PMID 23818978, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The dmr1-2 mutant allele confers increased resistance to Fusarium culmorum and F. graminearum silique infection, and decreased colonisation of rosette leaves. The dmr1-1 allele supports less rosette leaf colonisation but has wild type silique resistance.
      Title: Mutations in the Arabidopsis homoserine kinase gene DMR1 confer enhanced resistance to Fusarium culmorum and F. graminearum.
    2. Data indicate that pathogen resistance by impairment of PMR4 (callose synthase 12) and DMR1 (homoserine kinase) is conserved between Arabidopsis and Tomato.
      Title: Powdery mildew resistance in tomato by impairment of SlPMR4 and SlDMR1.
    3. Six independent dmr1 mutants each carry a different amino acid substitution in the HSK protein. Data provide evidence that homoserine accumulation in the chloroplast triggers a novel form of downy mildew resistance.
      Title: Downy mildew resistance in Arabidopsis by mutation of HOMOSERINE KINASE.
    4. HSK overexpression had no effect on the level of soluble homoserine phosphate, methionine and threonine/me
      Title: Methionine and threonine synthesis are limited by homoserine availability and not the activity of homoserine kinase in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_127281.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables homoserine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within methionine biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within photoperiodism, flowering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to fungus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in threonine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within threonine biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    located_in chloroplast stroma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    homoserine kinase
    NP_179318.1
    • homoserine kinase (HSK); FUNCTIONS IN: homoserine kinase activity; INVOLVED IN: methionine biosynthetic process, threonine biosynthetic process, response to fungus, response to bacterium; LOCATED IN: chloroplast stroma, chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: GHMP kinase, ATP-binding, conserved site (InterPro:IPR006203), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568), GHMP kinase (InterPro:IPR006204), Ribosomal protein S5 domain 2-type fold, subgroup (InterPro:IPR014721), Homoserine kinase (InterPro:IPR000870), GHMP kinase, C-terminal (InterPro:IPR013750); BEST Arabidopsis thaliana protein match is: homoserine kinase, putative / HSK, putative (TAIR:AT4G35295.1); Has 6092 Blast hits to 6088 proteins in 1935 species: Archae - 296; Bacteria - 4868; Metazoa - 7; Fungi - 124; Plants - 47; Viruses - 0; Other Eukaryotes - 750 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      7508473..7509887
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127281.2 → NP_179318.1  homoserine kinase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179318.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7FLV1, Q8L7R2, Q9XEE0
      UniProtKB/TrEMBL
      A0A5S9WYY6, A0A654ETK6
      Conserved Domains (2) summary
      PLN02451
      Location:1 → 370
      PLN02451; homoserine kinase
      pfam08544
      Location:270 → 342
      GHMP_kinases_C; GHMP kinases C terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8L7R2.1

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