LanA Laminin A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: LanAprovided by FlyBase
Official Full Name: Laminin Aprovided by FlyBase
Primary source: FLYBASE:FBgn0002526
Locus tag: Dmel_CG10236
See related: AllianceGenome:FB:FBgn0002526
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 5]]; alpha3/5; alpha[[3; CG10236; CT28769; Dmel\CG10236; FBgn0002526; FBtr0077014; hdln; Lam; Lam-A; lamA; LamA; Laminin; laminin alpha3/5; Lan; lanA; LM-A/alpha1; LMalpha1
Summary: Predicted to be an extracellular matrix structural constituent. Involved in several processes, including dorsal trunk growth, open tracheal system; melanotic encapsulation of foreign target; and negative regulation of synaptic assembly at neuromuscular junction. Located in basement membrane and presynaptic periactive zone. Is expressed in several structures, including embryonic/larval midgut primordium; germ layer; glial cell; head epidermis primordium; and hemocyte. Human ortholog(s) of this gene implicated in familial nephrotic syndrome; junctional epidermolysis bullosa; and lung small cell carcinoma. Orthologous to several human genes including LAMA5 (laminin subunit alpha 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 65A8-65A9; 3-16 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (6203831..6218022, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (6196931..6211122, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data indicate that synaptic activities down-regulate levels of the retrograde signal LanA to promote neuromuscular junction growth
Title: Activity-dependent retrograde laminin A signaling regulates synapse growth at Drosophila neuromuscular junctions.
Scarface has a key role in regulating the polarized localization of laminin A in this developmental context.
Title: Scarface, a secreted serine protease-like protein, regulates polarized localization of laminin A at the basement membrane of the Drosophila embryo.
results suggest an evolutionarily conserved role of a member of the laminin gene family in contributing to variation in weight and body composition
Title: Genetic variation in a member of the laminin gene family affects variation in body composition in Drosophila and humans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in basement membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion mediated by integrin	IDA Inferred from Direct Assay more info	PubMed
involved_in dorsal trunk growth, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in melanotic encapsulation of foreign target	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in regulation of embryonic development	IEA Inferred from Electronic Annotation more info
involved_in substrate adhesion-dependent cell spreading	IDA Inferred from Direct Assay more info	PubMed
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in basement membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in presynaptic periactive zone	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: laminin A

Names: CG10236-PA; LanA-PA; alpha3,5 laminin; headline; laminin; laminin A chain; laminin A subunit; laminin A5; laminin alpha; laminin alpha-chain; laminin alpha3,5; laminin alpha[[3,5]]; lamininA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

6203831..6218022 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057269.3 → NP_476617.1 laminin A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476617.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q00174, Q9VRW0

Related

FBpp0076722

Conserved Domains (11) summary

smart00136
Location:18 → 271

LamNT; Laminin N-terminal domain (domain VI)

smart00180
Location:1859 → 1907

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:1632 → 1760

LamB; Laminin B domain

smart00282
Location:3078 → 3205

LamG; Laminin G domain

COG0840
Location:2278 → 2662

Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]

cd00055
Location:631 → 673

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:2878 → 3029

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd02795
Location:831 → 966

CBM6-CBM35-CBM36_like; Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily

pfam00053
Location:541 → 589

Laminin_EGF; Laminin EGF domain

pfam06008
Location:2129 → 2385

Laminin_I; Laminin Domain I

pfam06009
Location:2566 → 2700

Laminin_II; Laminin Domain II