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    CLC-F chloride channel F [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842011, updated on 18-Sep-2024

    Summary

    Official Symbol
    CLC-F
    Official Full Name
    chloride channel F
    Primary source
    TAIR:AT1G55620
    Locus tag
    AT1G55620
    See related
    Araport:AT1G55620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCLC-F; chloride channel F; CHLORIDE CHANNEL F; CLCF; F20N2.5
    Summary
    Encodes a chloride channel protein that has been localized to the chloroplast and golgi apparatus. Complements yeast gef1 mutant and therefor may function to acidify the golgi lumen.
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    Genomic context

    See CLC-F in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (20787074..20791208, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene BRI1 like Neighboring gene tRNA-Ser Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein

    General gene information

    NM_104438.4
    NM_179482.3

    Gene Ontology Provided by TAIR

    Component Evidence Code Pubs
    located_in Golgi apparatus PubMed 
    located_in Golgi apparatus PubMed 
    located_in chloroplast PubMed 

    General protein information

    Preferred Names
    chloride channel F
    NP_564698.1
    • chloride channel F (CLC-F); FUNCTIONS IN: ion channel activity, voltage-gated chloride channel activity; INVOLVED IN: chloride transport, transmembrane transport; LOCATED IN: Golgi apparatus, chloroplast, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Chloride channel, core (InterPro:IPR014743), Chloride channel, voltage gated (InterPro:IPR001807), Cystathionine beta-synthase, core (InterPro:IPR000644); BEST Arabidopsis thaliana protein match is: chloride channel E (TAIR:AT4G35440.1); Has 8626 Blast hits to 8538 proteins in 2008 species: Archae - 276; Bacteria - 6042; Metazoa - 796; Fungi - 384; Plants - 229; Viruses - 0; Other Eukaryotes - 899 (source: NCBI BLink).
    NP_849813.1
    • chloride channel F (CLC-F); FUNCTIONS IN: ion channel activity, voltage-gated chloride channel activity; INVOLVED IN: chloride transport, transmembrane transport; LOCATED IN: Golgi apparatus, chloroplast, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Chloride channel, core (InterPro:IPR014743), Chloride channel, voltage gated (InterPro:IPR001807), Cystathionine beta-synthase, core (InterPro:IPR000644); BEST Arabidopsis thaliana protein match is: chloride channel E (TAIR:AT4G35440.2); Has 8610 Blast hits to 8392 proteins in 1951 species: Archae - 280; Bacteria - 6051; Metazoa - 795; Fungi - 382; Plants - 225; Viruses - 0; Other Eukaryotes - 877 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      20787074..20791208 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104438.4 → NP_564698.1  chloride channel F [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564698.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8RXR2, Q9ARM3, Q9LG04
      UniProtKB/TrEMBL
      A0A178W259, A0A5S9WM51, A0A7G2E1E1
      Conserved Domains (3) summary
      PLN02274
      Location:567 → 673
      PLN02274; inosine-5'-monophosphate dehydrogenase
      cd00400
      Location:139 → 544
      Voltage_gated_ClC; CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This ...
      cd04592
      Location:621 → 754
      CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria
    2. NM_179482.3 → NP_849813.1  chloride channel F [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849813.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8RXR2
      Conserved Domains (3) summary
      PLN02274
      Location:371 → 477
      PLN02274; inosine-5'-monophosphate dehydrogenase
      cd00400
      Location:3 → 348
      Voltage_gated_ClC; CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This ...
      cd04592
      Location:425 → 558
      CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria
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