U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    GTB1 global transcription factor group B1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842855, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    GTB1
    Official Full Name
    global transcription factor group B1
    Primary source
    TAIR:AT1G65440
    Locus tag
    AT1G65440
    See related
    Araport:AT1G65440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    GLOBAL TRANSCRIPTION FACTOR GROUP B; global transcription factor group B1; T8F5.22; T8F5_22
    Summary
    Related to yeast Spt6 protein, which functions as part of a protein complex in transcription initiation and also plays a role in chromatin structure / assembly.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See GTB1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    18
    Sequence:
    Chromosome: 1; NC_003070.9 (24306545..24314639, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene F-box/kelch-repeat protein Neighboring gene IBR domain-containing protein Neighboring gene HXXXD-type acyl-transferase family protein Neighboring gene chromatin assembly factor-1 (FASCIATA1) (FAS1)

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A conserved Pol II elongator SPT6L mediates Pol V transcription to regulate RNA-directed DNA methylation in Arabidopsis. Liu Y, et al. Nat Commun, 2024 May 25. PMID 38796517, Free PMC Article
    2. RNA polymerase II-independent recruitment of SPT6L at transcription start sites in Arabidopsis. Chen C, et al. Nucleic Acids Res, 2019 Jul 26. PMID 31127286, Free PMC Article
    3. SPT6L encoding a putative WG/GW-repeat protein regulates apical-basal polarity of embryo in Arabidopsis. Gu XL, et al. Mol Plant, 2012 Jan. PMID 21948524
    4. Transcription elongator SPT6L regulates the occupancies of the SWI2/SNF2 chromatin remodelers SYD/BRM and nucleosomes at transcription start sites in Arabidopsis. Shu J, et al. Nucleic Acids Res, 2022 Dec 9. PMID 36453990, Free PMC Article
    5. Arabidopsis IWS1 interacts with transcription factor BES1 and is involved in plant steroid hormone brassinosteroid regulated gene expression. Li L, et al. Proc Natl Acad Sci U S A, 2010 Feb 23. PMID 20139304, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A conserved Pol II elongator SPT6L mediates Pol V transcription to regulate RNA-directed DNA methylation in Arabidopsis.
      Title: A conserved Pol II elongator SPT6L mediates Pol V transcription to regulate RNA-directed DNA methylation in Arabidopsis.
    2. Transcription elongator SPT6L regulates the occupancies of the SWI2/SNF2 chromatin remodelers SYD/BRM and nucleosomes at transcription start sites in Arabidopsis.
      Title: Transcription elongator SPT6L regulates the occupancies of the SWI2/SNF2 chromatin remodelers SYD/BRM and nucleosomes at transcription start sites in Arabidopsis.
    3. SPT6L plays its conserved role in facilitating RNAPII occupancy across transcribed genes. Its enrichment is unexpectedly shifted, from gene body to transcription start site (TSS), when its association with RNAPII is disrupted. The HtH and YqgF domains are required for the TSS association. Recruitment of SPT6L at TSS is indispensable for its spreading along the gene body during transcription. [SPT6L]
      Title: RNA polymerase II-independent recruitment of SPT6L at transcription start sites in Arabidopsis.
    4. SPT6L encoding a putative WG/GW-repeat protein regulates apical-basal polarity of embryo.
      Title: SPT6L encoding a putative WG/GW-repeat protein regulates apical-basal polarity of embryo in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_001084306.2
    NM_001198388.1
    NM_001334206.1
    NM_105218.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription elongation-coupled chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    global transcription factor group B1
    NP_001077775.1
    • global transcription factor group B1 (GTB1); FUNCTIONS IN: transcription elongation regulator activity, hydrolase activity, acting on ester bonds, RNA binding; INVOLVED IN: chromatin assembly or disassembly, transcription initiation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Resolvase, RNase H-like fold (InterPro:IPR006641), Nucleic acid-binding, OB-fold (InterPro:IPR012340), Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Ribosomal protein S1, RNA-binding domain (InterPro:IPR003029), Transcription elongation factor Spt6 (InterPro:IPR017072); BEST Arabidopsis thaliana protein match is: Transcription elongation factor Spt6 (TAIR:AT1G63210.1); Has 59515 Blast hits to 32300 proteins in 2671 species: Archae - 146; Bacteria - 13496; Metazoa - 17051; Fungi - 6893; Plants - 5011; Viruses - 737; Other Eukaryotes - 16181 (source: NCBI BLink).
    NP_001185317.1
    • global transcription factor group B1 (GTB1); FUNCTIONS IN: transcription elongation regulator activity, hydrolase activity, acting on ester bonds, RNA binding; INVOLVED IN: chromatin assembly or disassembly, transcription initiation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Resolvase, RNase H-like fold (InterPro:IPR006641), Nucleic acid-binding, OB-fold (InterPro:IPR012340), Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Ribosomal protein S1, RNA-binding domain (InterPro:IPR003029), Transcription elongation factor Spt6 (InterPro:IPR017072); BEST Arabidopsis thaliana protein match is: Transcription elongation factor Spt6 (TAIR:AT1G63210.1).
    NP_176723.3
    • global transcription factor group B1 (GTB1); FUNCTIONS IN: transcription elongation regulator activity, hydrolase activity, acting on ester bonds, RNA binding; INVOLVED IN: chromatin assembly or disassembly, transcription initiation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Resolvase, RNase H-like fold (InterPro:IPR006641), Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), SH2 motif (InterPro:IPR000980), Ribosomal protein S1, RNA-binding domain (InterPro:IPR003029), Transcription elongation factor Spt6 (InterPro:IPR017072); BEST Arabidopsis thaliana protein match is: Transcription elongation factor Spt6 (TAIR:AT1G63210.1); Has 154550 Blast hits to 61131 proteins in 3458 species: Archae - 353; Bacteria - 39994; Metazoa - 50717; Fungi - 13479; Plants - 12820; Viruses - 1975; Other Eukaryotes - 35212 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      24306545..24314639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105218.5 → NP_176723.3  global transcription factor group B1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176723.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MS85, O80815, Q0WN83
      UniProtKB/TrEMBL
      A0A178W8K9, A0A5S9WS40
      Conserved Domains (11) summary
      smart00732
      Location:716 → 833
      YqgFc; Likely ribonuclease with RNase H fold
      smart00316
      Location:1102 → 1174
      S1; Ribosomal protein S1-like RNA-binding domain
      cd09918
      Location:1225 → 1313
      SH2_Nterm_SPT6_like; N-terminal Src homology 2 (SH2) domain found in Spt6
      cd09928
      Location:1324 → 1410
      SH2_Cterm_SPT6_like; C-terminal Src homology 2 (SH2) domain found in Spt6
      COG2183
      Location:320 → 1222
      Tex; Transcriptional accessory protein Tex/SPT6 [Transcription]
      pfam09371
      Location:340 → 568
      Tex_N; Tex-like protein N-terminal domain
      pfam14632
      Location:86 → 117
      SPT6_acidic; Acidic N-terminal SPT6
      pfam14633
      Location:1205 → 1409
      SH2_2; SH2 domain
      pfam14641
      Location:292 → 403
      HTH_44; Helix-turn-helix DNA-binding domain of SPT6
      pfam14878
      Location:991 → 1096
      DLD; Death-like domain of SPT6
      cl22429
      Location:875 → 975
      HHH_5; Helix-hairpin-helix domain

    2. NM_001198388.1 → NP_001185317.1  global transcription factor group B1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185317.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W8K9, A0A5S9WS40, F4I9Y9
      Conserved Domains (11) summary
      smart00732
      Location:687 → 804
      YqgFc; Likely ribonuclease with RNase H fold
      smart00316
      Location:1073 → 1145
      S1; Ribosomal protein S1-like RNA-binding domain
      cd09918
      Location:1196 → 1284
      SH2_Nterm_SPT6_like; N-terminal Src homology 2 (SH2) domain found in Spt6
      cd09928
      Location:1295 → 1381
      SH2_Cterm_SPT6_like; C-terminal Src homology 2 (SH2) domain found in Spt6
      COG2183
      Location:291 → 1193
      Tex; Transcriptional accessory protein Tex/SPT6 [Transcription]
      pfam09371
      Location:311 → 539
      Tex_N; Tex-like protein N-terminal domain
      pfam14632
      Location:57 → 88
      SPT6_acidic; Acidic N-terminal SPT6
      pfam14633
      Location:1176 → 1380
      SH2_2; SH2 domain
      pfam14641
      Location:263 → 374
      HTH_44; Helix-turn-helix DNA-binding domain of SPT6
      pfam14878
      Location:962 → 1067
      DLD; Death-like domain of SPT6
      cl22429
      Location:846 → 946
      HHH_5; Helix-hairpin-helix domain

    3. NM_001334206.1 → NP_001321759.1  global transcription factor group B1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MS85, O80815, Q0WN83
      UniProtKB/TrEMBL
      A0A178W8K9, A0A5S9WS40

    4. NM_001084306.2 → NP_001077775.1  global transcription factor group B1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077775.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W8K9, A0A5S9WS40, F4I9Y7
      Conserved Domains (11) summary
      smart00732
      Location:716 → 833
      YqgFc; Likely ribonuclease with RNase H fold
      smart00316
      Location:1102 → 1174
      S1; Ribosomal protein S1-like RNA-binding domain
      cd09918
      Location:1225 → 1313
      SH2_Nterm_SPT6_like; N-terminal Src homology 2 (SH2) domain found in Spt6
      cd09928
      Location:1324 → 1410
      SH2_Cterm_SPT6_like; C-terminal Src homology 2 (SH2) domain found in Spt6
      COG2183
      Location:320 → 1222
      Tex; Transcriptional accessory protein Tex/SPT6 [Transcription]
      pfam09371
      Location:340 → 568
      Tex_N; Tex-like protein N-terminal domain
      pfam14632
      Location:86 → 117
      SPT6_acidic; Acidic N-terminal SPT6
      pfam14633
      Location:1205 → 1409
      SH2_2; SH2 domain
      pfam14641
      Location:292 → 403
      HTH_44; Helix-turn-helix DNA-binding domain of SPT6
      pfam14878
      Location:991 → 1096
      DLD; Death-like domain of SPT6
      cl22429
      Location:875 → 975
      HHH_5; Helix-hairpin-helix domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8MS85.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.