VHA-A2 vacuolar proton ATPase A2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: VHA-A2
Official Full Name: vacuolar proton ATPase A2
Primary source: TAIR:AT2G21410
Locus tag: AT2G21410
See related: Araport:AT2G21410
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F3K23.17; F3K23_17; vacuolar proton ATPase A2
Summary: Vacuolar proton ATPase subunit VHA-a isoform 2. Localized in the tonoplast. Required for efficient nutrient storage but not for sodium accumulation.
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Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Vacuolar H[+]-ATPase and BZR1 form a feedback loop to regulate the homeostasis of BR signaling in Arabidopsis.
Title: Vacuolar H(+)-ATPase and BZR1 form a feedback loop to regulate the homeostasis of BR signaling in Arabidopsis.
A Defective Vacuolar Proton Pump Enhances Aluminum Tolerance by Reducing Vacuole Sequestration of Organic Acids.
Title: A Defective Vacuolar Proton Pump Enhances Aluminum Tolerance by Reducing Vacuole Sequestration of Organic Acids.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_127713.4

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	ISS Inferred from Sequence or Structural Similarity more info
enables diphosphate hydrolysis-driven proton transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to nutrient levels	IGI Inferred from Genetic Interaction more info	PubMed
NOT involved_in cellular response to salt stress	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within proton motive force-driven ATP synthesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of auxin polar transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sequestering of zinc ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vacuolar proton-transporting V-type ATPase complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vacuolar sequestering	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	HDA more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in mitochondrion	HDA more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed
located_in plant-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
located_in vacuolar membrane	HDA more info	PubMed
part_of vacuolar proton-transporting V-type ATPase, V0 domain	IEA Inferred from Electronic Annotation more info
located_in vacuole	HDA more info	PubMed

NP_179736.1

vacuolar proton ATPase A2 (VHA-A2); FUNCTIONS IN: ATPase activity, hydrogen-translocating pyrophosphatase activity; INVOLVED IN: cellular response to nutrient levels, ATP synthesis coupled proton transport; LOCATED IN: in 8 components; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, V0/A0 complex, 116kDa subunit (InterPro:IPR002490); BEST Arabidopsis thaliana protein match is: vacuolar proton ATPase A3 (TAIR:AT4G39080.1); Has 2867 Blast hits to 2293 proteins in 720 species: Archae - 334; Bacteria - 1213; Metazoa - 663; Fungi - 202; Plants - 115; Viruses - 0; Other Eukaryotes - 340 (source: NCBI BLink).