Cad99C Cadherin 99C [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cad99Cprovided by FlyBase
Official Full Name: Cadherin 99Cprovided by FlyBase
Primary source: FLYBASE:FBgn0039709
Locus tag: Dmel_CG31009
See related: AllianceGenome:FB:FBgn0039709
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CA-10; cad99C; Cad99c; CG15511; CG310034; CG31009; CG7805; CT35624; CT4930; DCad99C; Dm Cad99C; Dmel\CG31009
Summary: Enables myosin binding activity. Involved in several processes, including apical protein localization; follicle cell microvillus organization; and positive regulation of clathrin-dependent endocytosis. Located in apical plasma membrane and microvillus. Colocalizes with brush border membrane and endosome. Is expressed in cone cell; follicle cell; and oocyte. Human ortholog(s) of this gene implicated in Usher syndrome type 1D; Usher syndrome type 1F; and autosomal recessive nonsyndromic deafness 23. Orthologous to human PCDH15 (protocadherin related 15). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 99C3-99C4; 3-99 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (29841657..29854699)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (25667379..25680421)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cad99C is required to regulate cell rearrangement during salivary tube elongation.
Title: Cadherin 99C regulates apical expansion and cell rearrangement during epithelial tube elongation.
Hedgehog-regulated transcription factor induces high-level expression of Cad99C.
Title: Cadherin Cad99C is regulated by Hedgehog signaling in Drosophila.
Cad99C as a critical regulator of microvillus length, the first example of a transmembrane protein that is involved in this process.
Title: Drosophila melanogaster Cad99C, the orthologue of human Usher cadherin PCDH15, regulates the length of microvilli.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm2223 (e-PCR)
- UniSTS:10731

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISM Inferred from Sequence Model more info	PubMed
enables myosin binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apical protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	NAS Non-traceable Author Statement more info	PubMed
involved_in calcium-mediated signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion mediated by cadherin	ISM Inferred from Sequence Model more info	PubMed
involved_in chorion-containing eggshell formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell microvillus organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in mucosal immune response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mucosal immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of clathrin-dependent endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of follicle cell microvillus length	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tube morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vitelline membrane formation involved in chorion-containing eggshell formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with brush border membrane	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with endosome	IDA Inferred from Direct Assay more info	PubMed
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed