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    TTN7 Structural maintenance of chromosomes (SMC) family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817259, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TTN7
    Official Full Name
    Structural maintenance of chromosomes (SMC) family protein
    Primary source
    TAIR:AT2G27170
    Locus tag
    AT2G27170
    See related
    Araport:AT2G27170
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    SMC3; STRUCTURAL MAINTENANCE OF CHROMOSOMES 3; T22O13.6; TITAN7
    Summary
    Encodes a member of the Arabidopsis cohesin complex that is essential for viability and sister chromatid alignment.
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    Genomic context

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    See TTN7 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    29
    Sequence:
    Chromosome: 2; NC_003071.7 (11609073..11617496, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene low-molecular-weight cysteine-rich 9 Neighboring gene abscisic aldehyde oxidase 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene purple acid phosphatase 12

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of Arabidopsis thaliana SMC1 and SMC3: evidence that AtSMC3 may function beyond chromosome cohesion. Lam WS, et al. J Cell Sci, 2005 Jul 15. PMID 15972315
    2. Condensin and cohesin knockouts in Arabidopsis exhibit a titan seed phenotype. Liu Cm CM, et al. Plant J, 2002 Feb. PMID 11846874
    3. Cohesin gene defects may impair sister chromatid alignment and genome stability in Arabidopsis thaliana. Schubert V, et al. Chromosoma, 2009 Oct. PMID 19533160
    4. Arabidopsis plasmodesmal proteome. Fernandez-Calvino L, et al. PLoS One, 2011 Apr 20. PMID 21533090, Free PMC Article
    5. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001084499.2
    NM_001336108.1
    NM_001336109.1
    NM_128275.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cohesin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Structural maintenance of chromosomes (SMC) family protein
    NP_001077968.1
    • TITAN7 (TTN7); FUNCTIONS IN: ATP binding; INVOLVED IN: sister chromatid cohesion, chromosome segregation; LOCATED IN: cohesin complex, nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: SMCs flexible hinge (InterPro:IPR010935), RecF/RecN/SMC protein, N-terminal (InterPro:IPR003395); BEST Arabidopsis thaliana protein match is: structural maintenance of chromosomes 2 (TAIR:AT5G62410.1); Has 158776 Blast hits to 77347 proteins in 3496 species: Archae - 2059; Bacteria - 28403; Metazoa - 67946; Fungi - 11949; Plants - 6773; Viruses - 706; Other Eukaryotes - 40940 (source: NCBI BLink).
    NP_180285.4
    • TITAN7 (TTN7); FUNCTIONS IN: ATP binding; INVOLVED IN: sister chromatid cohesion, chromosome segregation; LOCATED IN: cohesin complex, nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: SMCs flexible hinge (InterPro:IPR010935), RecF/RecN/SMC protein, N-terminal (InterPro:IPR003395); BEST Arabidopsis thaliana protein match is: structural maintenance of chromosomes 2 (TAIR:AT5G62410.1); Has 158776 Blast hits to 77347 proteins in 3496 species: Archae - 2059; Bacteria - 28403; Metazoa - 67946; Fungi - 11949; Plants - 6773; Viruses - 706; Other Eukaryotes - 40940 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      11609073..11617496 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128275.5 → NP_180285.4  Structural maintenance of chromosomes (SMC) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180285.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WNE4, Q0WWN8, Q56YN8, Q56ZJ9, Q6QU76, Q8H2D2, Q8S8B4, Q9SHT1
      UniProtKB/TrEMBL
      A0A178W205
      Conserved Domains (5) summary
      cd03272
      Location:3 → 166
      ABC_SMC3_euk; ATP-binding cassette domain of eukaryotic SMC3 proteins
      smart00968
      Location:522 → 633
      SMC_hinge; SMC proteins Flexible Hinge Domain
      COG1196
      Location:1 → 1196
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl03951
      Location:185 → 288
      CDC37_N; Cdc37 N terminal kinase binding
      cl21455
      Location:1070 → 1185
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001336108.1 → NP_001324367.1  Structural maintenance of chromosomes (SMC) family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W205, A0A1P8AZX9

    3. NM_001084499.2 → NP_001077968.1  Structural maintenance of chromosomes (SMC) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077968.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WNE4, Q0WWN8, Q56YN8, Q56ZJ9, Q6QU76, Q8H2D2, Q8S8B4, Q9SHT1
      UniProtKB/TrEMBL
      A0A178W205
      Conserved Domains (5) summary
      cd03272
      Location:3 → 166
      ABC_SMC3_euk; ATP-binding cassette domain of eukaryotic SMC3 proteins
      smart00968
      Location:522 → 633
      SMC_hinge; SMC proteins Flexible Hinge Domain
      COG1196
      Location:1 → 1196
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl03951
      Location:185 → 288
      CDC37_N; Cdc37 N terminal kinase binding
      cl21455
      Location:1070 → 1185
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. NM_001336109.1 → NP_001324368.1  Structural maintenance of chromosomes (SMC) family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W205, A0A1P8AZX9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q56YN8.1

    Gene LinkOut

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