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    GGH1 gamma-glutamyl hydrolase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844202, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GGH1
    Official Full Name
    gamma-glutamyl hydrolase 1
    Primary source
    TAIR:AT1G78660
    Locus tag
    AT1G78660
    See related
    Araport:AT1G78660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATGGH1; gamma-glutamyl hydrolase 1; T30F21.1; T30F21_1
    Summary
    The Arabidopsis protein AtGGH1 is a gamma-glutamyl hydrolase cleaving pentaglutamates to yield di- and triglutamates. The enzyme is involved in the tetrahydrofolate metabolism and located to the vacuole.
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    Genomic context

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    See GGH1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    12
    Sequence:
    Chromosome: 1; NC_003070.9 (29585677..29588389)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene B3 domain protein Neighboring gene DNA-directed DNA polymerase Neighboring gene gamma-glutamyl hydrolase 3 Neighboring gene gamma-glutamyl hydrolase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Plant gamma-glutamyl hydrolases and folate polyglutamates: characterization, compartmentation, and co-occurrence in vacuoles. Orsomando G, et al. J Biol Chem, 2005 Aug 12. PMID 15961386
    2. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    NM_106513.5
    NM_179569.4
    NM_202443.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables gamma-glutamyl-peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables omega peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within tetrahydrofolylpolyglutamate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gamma-glutamyl hydrolase 1
    NP_177987.1
    • gamma-glutamyl hydrolase 1 (GGH1); CONTAINS InterPro DOMAIN/s: Peptidase C26, gamma-glutamyl hydrolase (InterPro:IPR015527), Peptidase C26 (InterPro:IPR011697); BEST Arabidopsis thaliana protein match is: gamma-glutamyl hydrolase 2 (TAIR:AT1G78680.1); Has 448 Blast hits to 444 proteins in 135 species: Archae - 0; Bacteria - 95; Metazoa - 194; Fungi - 0; Plants - 77; Viruses - 0; Other Eukaryotes - 82 (source: NCBI BLink).
    NP_849900.1
    • gamma-glutamyl hydrolase 1 (GGH1); CONTAINS InterPro DOMAIN/s: Peptidase C26, gamma-glutamyl hydrolase (InterPro:IPR015527), Peptidase C26 (InterPro:IPR011697); BEST Arabidopsis thaliana protein match is: gamma-glutamyl hydrolase 2 (TAIR:AT1G78680.1); Has 448 Blast hits to 444 proteins in 135 species: Archae - 0; Bacteria - 95; Metazoa - 194; Fungi - 0; Plants - 77; Viruses - 0; Other Eukaryotes - 82 (source: NCBI BLink).
    NP_974172.1
    • gamma-glutamyl hydrolase 1 (GGH1); CONTAINS InterPro DOMAIN/s: Peptidase C26, gamma-glutamyl hydrolase (InterPro:IPR015527), Peptidase C26 (InterPro:IPR011697); BEST Arabidopsis thaliana protein match is: gamma-glutamyl hydrolase 2 (TAIR:AT1G78680.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      29585677..29588389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_202443.3 → NP_974172.1  gamma-glutamyl hydrolase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974172.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q29Q19, Q93Z97, Q9SYL6
      UniProtKB/TrEMBL
      A0A178WAT7
      Conserved Domains (1) summary
      cl00020
      Location:57 → 329
      GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain

    2. NM_106513.5 → NP_177987.1  gamma-glutamyl hydrolase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177987.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q29Q19, Q93Z97, Q9SYL6
      UniProtKB/TrEMBL
      A0A178WAT7
      Conserved Domains (1) summary
      cl00020
      Location:57 → 329
      GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain

    3. NM_179569.4 → NP_849900.1  gamma-glutamyl hydrolase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849900.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WCK0, A0A5S9WVI3, A0A654F114
      Conserved Domains (1) summary
      cl00020
      Location:56 → 328
      GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SYL6.1

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