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    HMGB4 high mobility group B4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816263, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HMGB4
    Official Full Name
    high mobility group B4
    Primary source
    TAIR:AT2G17560
    Locus tag
    AT2G17560
    See related
    Araport:AT2G17560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    high mobility group B4; MJB20.12; MJB20_12; NFD04; NFD4; NUCLEOSOME/CHROMATIN ASSEMBLY FACTOR; NUCLEOSOME/CHROMATIN ASSEMBLY FACTOR D4
    Summary
    Encodes a protein belonging to the subgroup of HMGB (high mobility group B) proteins that have a distinctive DNA-binding motif, the HMG-box domain. The motif confers non-sequence specific interaction with linear DNA and structure-specific binding to distorted DNA sites. The HMGB proteins are involved in the assembly of nucleoprotein complexes. Can be phosphorylated by CK2alpha.
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    Genomic context

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    See HMGB4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Sequence:
    Chromosome: 2; NC_003071.7 (7642117..7643739, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene RB1-inducible coiled-coil protein Neighboring gene ncRNA Neighboring gene Undecaprenyl pyrophosphate synthetase family protein Neighboring gene Polynucleotide adenylyltransferase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleocytoplasmic distribution of the Arabidopsis chromatin-associated HMGB2/3 and HMGB4 proteins. Pedersen DS, et al. Plant Physiol, 2010 Dec. PMID 20940346, Free PMC Article
    2. Phosphorylation of maize and Arabidopsis HMGB proteins by protein kinase CK2alpha. Stemmer C, et al. Biochemistry, 2003 Apr 1. PMID 12653554
    3. Variability in Arabidopsis thaliana chromosomal high-mobility-group-1-like proteins. Stemmer C, et al. Eur J Biochem, 1997 Dec 15. PMID 9461286
    4. Regulation of leaf maturation by chromatin-mediated modulation of cytokinin responses. Efroni I, et al. Dev Cell, 2013 Feb 25. PMID 23449474, Free PMC Article
    5. Identification and characterization of nuclear pore complex components in Arabidopsis thaliana. Tamura K, et al. Plant Cell, 2010 Dec. PMID 21189294, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001036287.3
    NM_001084440.1
    NM_127310.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables chromatin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables structural constituent of chromatin TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    high mobility group B4
    NP_001031364.2
    • high mobility group B4 (HMGB4); FUNCTIONS IN: chromatin binding, structural constituent of chromatin, DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: chromatin assembly or disassembly; LOCATED IN: chromatin; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: High mobility group, superfamily (InterPro:IPR009071), High mobility group, HMG1/HMG2 (InterPro:IPR000910); BEST Arabidopsis thaliana protein match is: high mobility group B5 (TAIR:AT4G35570.1); Has 4827 Blast hits to 4510 proteins in 564 species: Archae - 0; Bacteria - 0; Metazoa - 3518; Fungi - 343; Plants - 550; Viruses - 3; Other Eukaryotes - 413 (source: NCBI BLink).
    NP_001077909.1
    • high mobility group B4 (HMGB4); FUNCTIONS IN: chromatin binding, structural constituent of chromatin, DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: chromatin assembly or disassembly; LOCATED IN: chromatin; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: High mobility group, superfamily (InterPro:IPR009071), High mobility group, HMG1/HMG2 (InterPro:IPR000910); BEST Arabidopsis thaliana protein match is: high mobility group B5 (TAIR:AT4G35570.1); Has 4787 Blast hits to 4472 proteins in 564 species: Archae - 0; Bacteria - 0; Metazoa - 3477; Fungi - 337; Plants - 547; Viruses - 5; Other Eukaryotes - 421 (source: NCBI BLink).
    NP_179347.1
    • high mobility group B4 (HMGB4); FUNCTIONS IN: chromatin binding, structural constituent of chromatin, DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: chromatin assembly or disassembly; LOCATED IN: chromatin; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: High mobility group, superfamily (InterPro:IPR009071), High mobility group, HMG1/HMG2 (InterPro:IPR000910); BEST Arabidopsis thaliana protein match is: high mobility group B5 (TAIR:AT4G35570.1); Has 4827 Blast hits to 4510 proteins in 564 species: Archae - 0; Bacteria - 0; Metazoa - 3518; Fungi - 343; Plants - 550; Viruses - 3; Other Eukaryotes - 413 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      7642117..7643739 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127310.3 → NP_179347.1  high mobility group B4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179347.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DG70, O49598, Q2V484, Q42344, Q8LCY0, Q94K96
      UniProtKB/TrEMBL
      A0A178VTN8, A0A5S9WZ17
      Conserved Domains (1) summary
      pfam00505
      Location:35 → 103
      HMG_box; HMG (high mobility group) box

    2. NM_001036287.3 → NP_001031364.2  high mobility group B4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031364.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DG70, O49598, Q2V484, Q42344, Q8LCY0, Q94K96
      UniProtKB/TrEMBL
      A0A178VTN8, A0A5S9WZ17
      Conserved Domains (1) summary
      pfam00505
      Location:35 → 103
      HMG_box; HMG (high mobility group) box

    3. NM_001084440.1 → NP_001077909.1  high mobility group B4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077909.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VTN8, A0A5S9WZ17
      Conserved Domains (1) summary
      pfam00505
      Location:35 → 103
      HMG_box; HMG (high mobility group) box
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q42344.1

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