DCAF12 DDB1 and CUL4 associated factor 12 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: DCAF12provided by FlyBase
Official Full Name: DDB1 and CUL4 associated factor 12provided by FlyBase
Primary source: FLYBASE:FBgn0037980
Locus tag: Dmel_CG3313
See related: AllianceGenome:FB:FBgn0037980
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3313; dcaf12; Dmel\CG3313
Summary: Enables ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including autophagic cell death; evoked neurotransmitter secretion; and positive regulation of hippo signaling. Part of Cul4-RING E3 ubiquitin ligase complex. Is active in cytoplasm; nucleus; and presynapse. Is expressed in organism. Orthologous to human DCAF12 (DDB1 and CUL4 associated factor 12); DCAF12L1 (DDB1 and CUL4 associated factor 12 like 1); and DCAF12L2 (DDB1 and CUL4 associated factor 12 like 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (12014943..12017031, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (7840665..7842753, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

DCAF12 promotes apoptosis and inhibits NF-kappaB activation by acting as an endogenous antagonist of IAPs.
Title: DCAF12 promotes apoptosis and inhibits NF-κB activation by acting as an endogenous antagonist of IAPs.
DCAF12 and Cul4 are critical for normal synaptic function and plasticity at larval neuromuscular junctions.
Title: Cul4 ubiquitin ligase cofactor DCAF12 promotes neurotransmitter release and homeostatic plasticity.
Drosophila DCAF12 has a role in controlling apoptosis
Title: Control of apoptosis by Drosophila DCAF12.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in autophagic cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in evoked neurotransmitter secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of hippo signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul4-RING E3 ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed

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