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    NADK2 NAD kinase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838766, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NADK2
    Official Full Name
    NAD kinase 2
    Primary source
    TAIR:AT1G21640
    Locus tag
    AT1G21640
    See related
    Araport:AT1G21640
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATNADK2; F8K7.5; F8K7_5; NAD kinase 2; NAD KINASE 2
    Summary
    Encodes a protein with NAD kinase activity. The protein was also shown to bind calmodulin.
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    Genomic context

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    See NADK2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (7588414..7592890)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene pumilio 20 Neighboring gene Calcium-binding EF hand family protein Neighboring gene Preprotein translocase SecA family protein Neighboring gene zinc ion binding protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Metabolic changes associated with dark-induced leaf senescence in Arabidopsis nadk2 mutants. Chaomurilege, et al. Plant Signal Behav, 2023 Dec 31. PMID 37272565, Free PMC Article
    2. Chloroplast NAD kinase is essential for energy transduction through the xanthophyll cycle in photosynthesis. Takahashi H, et al. Plant Cell Physiol, 2006 Dec. PMID 17082216
    3. NADK2, an Arabidopsis chloroplastic NAD kinase, plays a vital role in both chlorophyll synthesis and chloroplast protection. Chai MF, et al. Plant Mol Biol, 2005 Nov. PMID 16244906
    4. Cloning and characterization of two NAD kinases from Arabidopsis. identification of a calmodulin binding isoform. Turner WL, et al. Plant Physiol, 2004 Jul. PMID 15247403, Free PMC Article
    5. Subcellular and tissue localization of NAD kinases from Arabidopsis: compartmentalization of de novo NADP biosynthesis. Waller JC, et al. Planta, 2010 Jan. PMID 19921251

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Metabolic changes associated with dark-induced leaf senescence in Arabidopsis nadk2 mutants.
      Title: Metabolic changes associated with dark-induced leaf senescence in Arabidopsis nadk2 mutants.
    2. The subcellular distribution of the three NADK isoforms was examined using NADK-green fluorescent protein (GFP) fusion proteins expressed transiently in Arabidopsis suspension-cultured cells.
      Title: Subcellular and tissue localization of NAD kinases from Arabidopsis: compartmentalization of de novo NADP biosynthesis.
    3. results suggest that NADK2 may be a chloroplast NAD kinase and play a vital role in chlorophyll synthesis and chloroplast protection against oxidative damage
      Title: NADK2, an Arabidopsis chloroplastic NAD kinase, plays a vital role in both chlorophyll synthesis and chloroplast protection.
    4. These results indicate that chloroplast NAD kinase (nadk2 gene), catalyzing phosphorylation of NAD, is essential for the proper photosynthetic machinery of PSII and the xanthophyll cycle.
      Title: Chloroplast NAD kinase is essential for energy transduction through the xanthophyll cycle in photosynthesis.
    Submit: New GeneRIF Correction

    General gene information

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    NM_102013.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD+ kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NAD metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NADP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    NAD kinase 2
    NP_001185057.1
    • NAD kinase 2 (NADK2); FUNCTIONS IN: NAD+ kinase activity, calmodulin binding; INVOLVED IN: pyridine nucleotide biosynthetic process, metabolic process; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATP-NAD kinase, PpnK-type, alpha/beta (InterPro:IPR017438), ATP-NAD kinase, PpnK-type (InterPro:IPR016064), ATP-NAD/AcoX kinase (InterPro:IPR002504), ATP-NAD kinase, PpnK-type, all-beta (InterPro:IPR017437); BEST Arabidopsis thaliana protein match is: NAD kinase 1 (TAIR:AT3G21070.2).
    NP_564145.1
    • NAD kinase 2 (NADK2); FUNCTIONS IN: NAD+ kinase activity, calmodulin binding; INVOLVED IN: pyridine nucleotide biosynthetic process, metabolic process; LOCATED IN: chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATP-NAD kinase, PpnK-type, alpha/beta (InterPro:IPR017438), ATP-NAD kinase, PpnK-type (InterPro:IPR016064), ATP-NAD/AcoX kinase (InterPro:IPR002504), ATP-NAD kinase, PpnK-type, all-beta (InterPro:IPR017437); BEST Arabidopsis thaliana protein match is: NAD kinase 1 (TAIR:AT3G21070.2); Has 8697 Blast hits to 8591 proteins in 2758 species: Archae - 277; Bacteria - 5531; Metazoa - 247; Fungi - 416; Plants - 137; Viruses - 0; Other Eukaryotes - 2089 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      7588414..7592890
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001198128.1 → NP_001185057.1  NAD kinase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185057.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WBY1, A0A5S9VG96, F4HY34
      Conserved Domains (2) summary
      PLN02727
      Location:13 → 999
      PLN02727; NAD kinase
      cl01255
      Location:665 → 998
      DAGK_cat; Diacylglycerol kinase catalytic domain

    2. NM_102013.5 → NP_564145.1  NAD kinase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564145.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C5W3, Q9XI15
      UniProtKB/TrEMBL
      A0A178WBY1, A0A5S9VG96
      Conserved Domains (2) summary
      PLN02727
      Location:13 → 985
      PLN02727; NAD kinase
      cl01255
      Location:665 → 984
      DAGK_cat; Diacylglycerol kinase catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C5W3.1

    Gene LinkOut

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