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    LACS1 AMP-dependent synthetase and ligase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819337, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LACS1
    Official Full Name
    AMP-dependent synthetase and ligase family protein
    Primary source
    TAIR:AT2G47240
    Locus tag
    AT2G47240
    See related
    Araport:AT2G47240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CER8; ECERIFERUM 8; LONG-CHAIN ACYL-COA SYNTHASE 1; T8I13.8
    Summary
    Encodes an acyl-CoA synthetase that acts on long-chain and very-long-chain fatty acids, involved in cuticular wax and cutin biosynthesis
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    Genomic context

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    See LACS1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    19
    Sequence:
    Chromosome: 2; NC_003071.7 (19392497..19397907)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene polyribonucleotide phosphorylase, putative (DOMAIN OF UNKNOWN FUNCTION 724 5) Neighboring gene agenet domain protein (DOMAIN OF UNKNOWN FUNCTION 724 6) Neighboring gene long chain acyl-CoA synthetase Neighboring gene RNA helicase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Combined activity of LACS1 and LACS4 is required for proper pollen coat formation in Arabidopsis. Jessen D, et al. Plant J, 2011 Nov. PMID 21790813
    2. Organ fusion and defective cuticle function in a lacs1 lacs2 double mutant of Arabidopsis. Weng H, et al. Planta, 2010 Apr. PMID 20237894
    3. Arabidopsis CER8 encodes LONG-CHAIN ACYL-COA SYNTHETASE 1 (LACS1) that has overlapping functions with LACS2 in plant wax and cutin synthesis. Lü S, et al. Plant J, 2009 Aug. PMID 19392700
    4. Leaf Epicuticular Waxes of the Eceriferum Mutants in Arabidopsis. Jenks MA, et al. Plant Physiol, 1995 May. PMID 12228482, Free PMC Article
    5. Insertional mutant analysis reveals that long-chain acyl-CoA synthetase 1 (LACS1), but not LACS8, functionally overlaps with LACS9 in Arabidopsis seed oil biosynthesis. Zhao L, et al. Plant J, 2010 Dec. PMID 21143684

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The combined inactivation of LACS1 and LACS4 in Arabidopsis resulted in conditional pollen sterility and impaired wax biosynthesis.
      Title: Combined activity of LACS1 and LACS4 is required for proper pollen coat formation in Arabidopsis.
    2. LACS1 is localized in the ER and functionally overlaps with LACS9 to supply acyl-CoAs for TAG biosynthesis.
      Title: Insertional mutant analysis reveals that long-chain acyl-CoA synthetase 1 (LACS1), but not LACS8, functionally overlaps with LACS9 in Arabidopsis seed oil biosynthesis.
    3. lacs1 lacs2 double-mutant plants displayed pleiotropic phenotypes including organ fusion, abnormal flower development and reduced seed set.
      Title: Organ fusion and defective cuticle function in a lacs1 lacs2 double mutant of Arabidopsis.
    4. LACS1 is a functionally novel acyl-CoA synthetase that preferentially modifies both VLCFAs for wax synthesis and long-chain (C16) fatty acids for cutin synthesis.
      Title: Arabidopsis CER8 encodes LONG-CHAIN ACYL-COA SYNTHETASE 1 (LACS1) that has overlapping functions with LACS2 in plant wax and cutin synthesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_001036477.1
    NM_001337254.1
    NM_001337255.1
    NM_130292.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables very long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cutin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within wax biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    AMP-dependent synthetase and ligase family protein
    NP_001318440.1
    • LONG-CHAIN ACYL-COA SYNTHASE 1 (LACS1); FUNCTIONS IN: long-chain fatty acid-CoA ligase activity, very long-chain fatty acid-CoA ligase activity; INVOLVED IN: fatty acid biosynthetic process, cutin biosynthetic process, wax biosynthetic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 29 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: AMP-dependent synthetase and ligase family protein (TAIR:AT4G23850.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_182246.1
    • LONG-CHAIN ACYL-COA SYNTHASE 1 (LACS1); FUNCTIONS IN: long-chain fatty acid-CoA ligase activity, very long-chain fatty acid-CoA ligase activity; INVOLVED IN: fatty acid biosynthetic process, cutin biosynthetic process, wax biosynthetic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 29 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: AMP-dependent synthetase and ligase family protein (TAIR:AT4G23850.1); Has 55133 Blast hits to 51773 proteins in 3295 species: Archae - 1024; Bacteria - 35525; Metazoa - 2495; Fungi - 1959; Plants - 1853; Viruses - 1; Other Eukaryotes - 12276 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      19392497..19397907
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130292.4 → NP_182246.1  AMP-dependent synthetase and ligase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_182246.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22898, Q56WP3, Q56ZG8
      UniProtKB/TrEMBL
      A0A5S9X7R0
      Conserved Domains (2) summary
      PLN02430
      Location:1 → 660
      PLN02430; long-chain-fatty-acid-CoA ligase
      cd05927
      Location:72 → 652
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    2. NM_001337254.1 → NP_001318440.1  AMP-dependent synthetase and ligase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22898, Q56WP3, Q56ZG8
      UniProtKB/TrEMBL
      A0A5S9X7R0

    3. NM_001036477.1 → NP_001031554.1  AMP-dependent synthetase and ligase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031554.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22898, Q56WP3, Q56ZG8
      UniProtKB/TrEMBL
      A0A5S9X7R0
      Conserved Domains (2) summary
      PLN02430
      Location:1 → 660
      PLN02430; long-chain-fatty-acid-CoA ligase
      cd05927
      Location:72 → 652
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    4. NM_001337255.1 → NP_001325159.1  AMP-dependent synthetase and ligase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VU16, A0A1P8B2B8, A0A5S9X7R0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O22898.1

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