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    HSP101 heat shock protein 101 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843771, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HSP101
    Official Full Name
    heat shock protein 101
    Primary source
    TAIR:AT1G74310
    Locus tag
    AT1G74310
    See related
    Araport:AT1G74310
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATHSP101; F1O17.2; F1O17_2; heat shock protein 101; HEAT SHOCK PROTEIN ATHSP101; HOT1
    Summary
    Encodes ClpB1, which belongs to the Casein lytic proteinase/heat shock protein 100 (Clp/Hsp100) family. Involved in refolding of proteins which form aggregates under heat stress. Also known as AtHsp101. AtHsp101 is a cytosolic heat shock protein required for acclimation to high temperature.
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    Genomic context

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    See HSP101 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Sequence:
    Chromosome: 1; NC_003070.9 (27936508..27940369, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene ncRNA Neighboring gene Protein kinase superfamily protein Neighboring gene Protein kinase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis plants overexpressing additional copies of heat shock protein Hsp101 showed high heat tolerance and endo-gene silencing. Babbar R, et al. Plant Sci, 2023 May. PMID 36796649
    2. An Arabidopsis heat shock protein complements a thermotolerance defect in yeast. Schirmer EC, et al. Plant Cell, 1994 Dec. PMID 7866032, Free PMC Article
    3. Genetic analysis reveals domain interactions of Arabidopsis Hsp100/ClpB and cooperation with the small heat shock protein chaperone system. Lee U, et al. Plant Cell, 2005 Feb. PMID 15659638, Free PMC Article
    4. The xenobiotic beta-aminobutyric acid enhances Arabidopsis thermotolerance. Zimmerli L, et al. Plant J, 2008 Jan. PMID 18047473
    5. Heat shock protein 101 effects in A. thaliana: genetic variation, fitness and pleiotropy in controlled temperature conditions. Tonsor SJ, et al. Mol Ecol, 2008 Mar. PMID 18321256, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis plants overexpressing additional copies of heat shock protein Hsp101 showed high heat tolerance and endo-gene silencing.
      Title: Arabidopsis plants overexpressing additional copies of heat shock protein Hsp101 showed high heat tolerance and endo-gene silencing.
    2. Heat shock protein 101 (HSP101) promotes flowering under nonstress conditions.
      Title: Heat shock protein 101 (HSP101) promotes flowering under nonstress conditions.
    3. after heat shock, HSP101 is required for the efficient release of RP mRNAs from stress granules resulting in a rapid restoration of the translation machinery by producing new ribosomal proteins.
      Title: Heat Shock Protein HSP101 Affects the Release of Ribosomal Protein mRNAs for Recovery after Heat Shock.
    4. Data show that both class I and II small heat shock proteins (sHSPs) were present in cytosolic foci, some of which colocalized with HSP101 and with eEF1Bgamma and eEF1Bbeta.
      Title: Class I and II Small Heat Shock Proteins Together with HSP101 Protect Protein Translation Factors during Heat Stress.
    5. a positive feedback loop between HSP101 and HSA32 at the protein level is a novel mechanism for prolonging the memory of heat acclimation.
      Title: Interplay between heat shock proteins HSP101 and HSA32 prolongs heat acclimation memory posttranscriptionally in Arabidopsis.
    6. This study shows that Hsp101 expression is evolvable in natural populations.Hsp101 is primarily an emergency high-temperature tolerance mechanism, since expression levels are lower in low-latitude populations from warmer climates.
      Title: Heat shock protein 101 effects in A. thaliana: genetic variation, fitness and pleiotropy in controlled temperature conditions.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001334640.1
    NM_106091.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
    acts_upstream_of_or_within positive regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein unfolding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to high light intensity IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    heat shock protein 101
    NP_565083.1
    • heat shock protein 101 (HSP101); FUNCTIONS IN: protein binding, ATPase activity, ATP binding; INVOLVED IN: response to high light intensity, response to hydrogen peroxide, response to heat, protein unfolding; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Clp ATPase, C-terminal (InterPro:IPR019489), ATPase, AAA+ type, core (InterPro:IPR003593), ATPase, AAA-2 (InterPro:IPR013093), ATPase, AAA-type, core (InterPro:IPR003959), Chaperonin clpA/B (InterPro:IPR001270), Chaperonin ClpA/B, conserved site (InterPro:IPR018368), Clp, N-terminal (InterPro:IPR004176); BEST Arabidopsis thaliana protein match is: casein lytic proteinase B2 (TAIR:AT4G14670.1); Has 27671 Blast hits to 24472 proteins in 3146 species: Archae - 360; Bacteria - 17866; Metazoa - 1124; Fungi - 430; Plants - 707; Viruses - 13; Other Eukaryotes - 7171 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      27936508..27940369 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106091.4 → NP_565083.1  heat shock protein 101 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565083.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P42730, Q8W4F2, Q9LE57
      UniProtKB/TrEMBL
      A0A5S9WUB5, A0A654EZK7
      Conserved Domains (1) summary
      TIGR03346
      Location:6 → 856
      chaperone_ClpB; ATP-dependent chaperone ClpB

    2. NM_001334640.1 → NP_001320516.1  heat shock protein 101 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W7U9, A0A1P8AN20, A0A384K8A9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42730.2

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