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    Dph5 Diphthamide methyltransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42663, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dph5provided by FlyBase
    Official Full Name
    Diphthamide methyltransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024558
    Locus tag
    Dmel_CG31289
    See related
    AllianceGenome:FB:FBgn0024558
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA.LD12153; BcDNA:LD12153; CG31289; CG5275; Dmel\CG31289; l(3)L4910
    Summary
    Predicted to enable diphthine methyl ester synthase activity. Involved in positive regulation of translation. Predicted to be located in cytoplasm. Is expressed in several structures, including Malpighian tubule primordium; embryonic anal pad; embryonic/larval midgut primordium; germline cell; and gut section. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties. Orthologous to human DPH5 (diphthamide biosynthesis 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Dph5 in Genome Data Viewer
    Location:
    94B5-94B5; 3-75 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22582028..22583225, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18407750..18408947, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene stuck in traffic Neighboring gene uncharacterized protein Neighboring gene COP9 signalosome subunit 6 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene buttonless

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Diphthamide modification of eEF2 is required for gut tumor-like hyperplasia induced by oncogenic Ras. Tsuda-Sakurai K, et al. Genes Cells, 2020 Feb. PMID 31828897
    2. Cloning, mapping and tissue-specific expression of Drosophila clathrin-associated protein AP50 gene. Zhang YQ, et al. Gene, 1999 Jun 11. PMID 10375633
    3. Nutritional Control of Stem Cell Division through S-Adenosylmethionine in Drosophila Intestine. Obata F, et al. Dev Cell, 2018 Mar 26. PMID 29587144
    4. Upregulation of ribosome biogenesis via canonical E-boxes is required for Myc-driven proliferation. Zielke N, et al. Dev Cell, 2022 Apr 25. PMID 35472319
    5. Dynamics of nuclear matrix proteome during embryonic development in Drosophila melanogaster. Varma P, et al. J Biosci, 2011 Aug. PMID 21799256

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables diphthine methyl ester synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein histidyl modification to diphthamide IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein histidyl modification to diphthamide ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    diphthamide methyltransferase
    Names
    CG31289-PA
    Dph5-PA
    NP_524452.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22582028..22583225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079728.5 → NP_524452.4  diphthamide methyltransferase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524452.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IN02
      Related
      FBpp0083673
      Conserved Domains (1) summary
      PTZ00175
      Location:1 → 270
      PTZ00175; diphthine synthase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IN02 Q8IN02

    Gene LinkOut

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