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    ARA-2 Ras-related small GTP-binding family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837151, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ARA-2
    Official Full Name
    Ras-related small GTP-binding family protein
    Primary source
    TAIR:AT1G06400
    Locus tag
    AT1G06400
    See related
    Araport:AT1G06400
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARA2; ARABIDOPSIS THALIANA RAB GTPASE HOMOLOG A1A; ATRAB11E; ATRABA1A; SMALL GTP-BINDING PROTEIN; T2D23.10; T2D23_10
    Summary
    small GTP-binding protein (ara-2)
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    Genomic context

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    See ARA-2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (1950596..1952880, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene Ribosomal protein L1p/L10e family Neighboring gene GSK3/SHAGGY-like protein kinase 1 Neighboring gene ncRNA Neighboring gene trehalose-phosphatase/synthase 7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proportional subcellular localization of Arabidopsis thaliana RabA1a. Kim H, et al. Plant Signal Behav, 2019. PMID 30764708, Free PMC Article
    2. Altered ARA2 (RABA1a) expression in Arabidopsis reveals the involvement of a Rab/YPT family member in auxin-mediated responses. Koh EJ, et al. Plant Mol Biol, 2009 May. PMID 19199049
    3. In vitro mutation analysis of Arabidopsis thaliana small GTP-binding proteins and detection of GAP-like activities in plant cells. Anai T, et al. FEBS Lett, 1994 Jun 13. PMID 8013629
    4. Isolation and analysis of cDNAs encoding small GTP-binding proteins of Arabidopsis thaliana. Anai T, et al. Gene, 1991 Dec 15. PMID 1748311
    5. Null mutants of individual RABA genes impact the proportion of different cell wall components in stem tissue of Arabidopsis thaliana. Lunn D, et al. PLoS One, 2013. PMID 24124508, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Involved in determining the composition of the cell wall, particularly with respect to pectin content, possibly through regulating trafficking of pectin from the Golgi to the apoplast. [RABA1A]
      Title: Null mutants of individual RABA genes impact the proportion of different cell wall components in stem tissue of Arabidopsis thaliana.
    2. ARA2 is an essential component of a pathway that couples auxin signaling to plant growth and development.
      Title: Altered ARA2 (RABA1a) expression in Arabidopsis reveals the involvement of a Rab/YPT family member in auxin-mediated responses.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_100520.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell wall biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to auxin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ras-related small GTP-binding family protein
    NP_172128.1
    • ARA-2; FUNCTIONS IN: GTP binding; INVOLVED IN: protein transport, small GTPase mediated signal transduction; LOCATED IN: plasma membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Ras GTPase (InterPro:IPR001806), Small GTP-binding protein (InterPro:IPR005225), Small GTPase (InterPro:IPR020851), Ras (InterPro:IPR013753), Ras small GTPase, Rab type (InterPro:IPR003579), Rab11-related (InterPro:IPR015595); BEST Arabidopsis thaliana protein match is: RAB GTPase homolog A1C (TAIR:AT5G45750.1); Has 26542 Blast hits to 26487 proteins in 734 species: Archae - 28; Bacteria - 140; Metazoa - 13950; Fungi - 3642; Plants - 2996; Viruses - 20; Other Eukaryotes - 5766 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      1950596..1952880 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100520.4 → NP_172128.1  Ras-related small GTP-binding family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172128.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P28185
      UniProtKB/TrEMBL
      A0A178W910, A0A5S9SZA5
      Conserved Domains (1) summary
      cd01868
      Location:11 → 175
      Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28185.1

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