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    XRCC1 XRCC1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31451, updated on 9-Dec-2024

    Summary

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    Official Symbol
    XRCC1provided by FlyBase
    Official Full Name
    XRCC1provided by FlyBase
    Primary source
    FLYBASE:FBgn0026751
    Locus tag
    Dmel_CG4208
    See related
    AllianceGenome:FB:FBgn0026751
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    4208; CG4208; Dmel\CG4208; Xrcc1
    Summary
    Predicted to enable damaged DNA binding activity. Predicted to be involved in base-excision repair. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); carcinoma (multiple); central nervous system cancer (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human XRCC1 (X-ray repair cross complementing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See XRCC1 in Genome Data Viewer
    Location:
    4F5-4F5; 1-11 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5329876..5332435)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5223909..5226468)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Something about silencing 10 Neighboring gene RNA-binding protein 4F Neighboring gene Minichromosome maintenance 3 Neighboring gene uncharacterized protein Neighboring gene Calcineurin B Neighboring gene small conductance calcium-activated potassium channel

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A cell cycle-specific requirement for the XRCC1 BRCT II domain during mammalian DNA strand break repair. Taylor RM, et al. Mol Cell Biol, 2000 Jan. PMID 10611252, Free PMC Article
    2. XRCC1 and CYP2E1 polymorphisms as susceptibility factors of plasma mutant p53 protein and anti-p53 antibody expression in vinyl chloride monomer-exposed polyvinyl chloride workers. Wong RH, et al. Cancer Epidemiol Biomarkers Prev, 2002 May. PMID 12010862
    3. Association of single nucleotide polymorphisms in ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with clinical and cellular radiosensitivity. Zschenker O, et al. Radiother Oncol, 2010 Oct. PMID 20170971
    4. Mcm3 replicative helicase mutation impairs neuroblast proliferation and memory in Drosophila. Blumröder R, et al. Genes Brain Behav, 2016 Sep. PMID 27283469, Free PMC Article
    5. Uracil-containing DNA in Drosophila: stability, stage-specific accumulation, and developmental involvement. Muha V, et al. PLoS Genet, 2012. PMID 22685418, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fibrosis in radiotherapy-treated breast neoplasms tends to be higher in patients being polymorphic in XRCC1 when compared to patients with wildtype genotype.
      Title: Association of single nucleotide polymorphisms in ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with clinical and cellular radiosensitivity.
    2. Individuals possessing more susceptible XRCC1 Gln-Gln genotypes were more likely to reveal p53 overexpression. Susceptible XRCC1 genotypes may modulate the mutation of the p53 gene among VCM-exposed workers.
      Title: XRCC1 and CYP2E1 polymorphisms as susceptibility factors of plasma mutant p53 protein and anti-p53 antibody expression in vinyl chloride monomer-exposed polyvinyl chloride workers.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in base-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in base-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via nonhomologous end joining IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in single strand break repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    XRCC1
    Names
    CG4208-PA
    XRCC1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      5329876..5332435
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_131989.4 → NP_572217.1  XRCC1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572217.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9UB07, Q9Y095
      Related
      FBpp0070730
      Conserved Domains (2) summary
      pfam00533
      Location:420 → 494
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam01834
      Location:1 → 144
      XRCC1_N; XRCC1 N terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UB07 Q9UB07
    Q9Y095 Q9Y095

    Gene LinkOut

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