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    stmA stambha A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35865, updated on 9-Dec-2024

    Summary

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    Official Symbol
    stmAprovided by FlyBase
    Official Full Name
    stambha Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086784
    Locus tag
    Dmel_CG8739
    See related
    AllianceGenome:FB:FBgn0086784
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8739; cmp44E; Dmel\CG8739; rbo; Rbo; RBO; stambhA; stm-A; StmA
    Summary
    Involved in bulk synaptic vesicle endocytosis; phototransduction; and synaptic vesicle exocytosis. Located in synapse. Is expressed in several structures, including adult antennal lobe; adult mushroom body; embryonic brain; germline cell; and organism subdivision. Orthologous to several human genes including EFR3B (EFR3 homolog B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See stmA in Genome Data Viewer
    Location:
    44E3-44E3; 2-59 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8729502..8734304, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4617007..4621809, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene germ cell-less Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene bloated Neighboring gene long non-coding RNA:CR44277

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects of mutations at the stambh A locus of Drosophila melanogaster. Kumar M, et al. J Genet, 2001 Aug. PMID 11910128
    2. Studies on paralysis and development of second chromosome temperature sensitive paralytic mutants of Drosophila melanogaster. Shyngle J, et al. Indian J Exp Biol, 1985 May. PMID 3935574
    3. Phenotypes of lethal alleles of the recessive temperature sensitive paralytic mutant stambh A of Drosophila melanogaster suggest its neurogenic function. Chandrashekaran S, et al. Genetica, 1993. PMID 8150294
    4. Clonal analysis of cmp44E, which encodes a conserved putative transmembrane protein, indicates a requirement for cell viability in Drosophila. Faulkner DL, et al. Dev Genet, 1998. PMID 9883579
    5. Rolling blackout, a newly identified PIP2-DAG pathway lipase required for Drosophila phototransduction. Huang FD, et al. Nat Neurosci, 2004 Oct. PMID 15361878

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study suggests the RBO-PI4KIIIalpha complex as a novel therapeutic target, and PI4KIIIalpha inhibitors as new drug candidates.
      Title: Downregulation of RBO-PI4KIIIα Facilitates Aβ(42) Secretion and Ameliorates Neural Deficits in Aβ(42)-Expressing Drosophila.
    2. This study showed that mutants in the gene stambhA (stmA),which encodes a phosphatidylinositol 4,5 bisphosphate-diacylglycerol lipase, exhibit reduction in the amplitudes of odor-evoked responses recorded from the antennal surface of adult Drosophila.
      Title: Drosophila mutants in phospholipid signaling have reduced olfactory responses as adults and larvae.
    3. Rolling blackout protein possesses both lipase domain-dependent and scaffolding functions with differential requirements in non-neuronal versus neuronal endocytosis mechanisms downstream of dynamin GTPase activity.
      Title: Drosophila rolling blackout displays lipase domain-dependent and -independent endocytic functions downstream of dynamin.
    4. The rolling blackout (rbo) gene encodes an integral plasma membrane lipase required for Drosophila phototransduction.
      Title: Rolling blackout, a newly identified PIP2-DAG pathway lipase required for Drosophila phototransduction.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in bulk synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phototransduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    stambha A
    Names
    CG8739-PA
    CG8739-PB
    CG8739-PC
    CG8739-PD
    CG8739-PE
    CG8739-PF
    conserved membrane protein at 44E
    rolling blackout
    stambh A
    stambhA
    stmA-PA
    stmA-PB
    stmA-PC
    stmA-PD
    stmA-PE
    stmA-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8729502..8734304 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165624.2 → NP_724710.1  stambha A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724710.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IGJ0
      Related
      FBpp0087794

    2. NM_001014513.2 → NP_001014513.1  stambha A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014513.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z7I7, A1Z7I8, A1Z7I9, O96648, Q7K2E8, Q8IGJ0

    3. NM_165625.2 → NP_724711.1  stambha A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724711.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IGJ0
      Related
      FBpp0087795

    4. NM_001299282.1 → NP_001286211.1  stambha A, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286211.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFU5

    5. NM_001382198.1 → NP_001369066.1  stambha A, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6M3Q7F3

    6. NM_001382199.1 → NP_001369067.1  stambha A, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6M3Q6Z1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LFU5 A0A0B4LFU5
    A0A6M3Q6Z1 A0A6M3Q6Z1
    A0A6M3Q7F3 A0A6M3Q7F3
    Q8IGJ0.3 Q8IGJ0

    Gene LinkOut

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