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    Stam Signal transducing adaptor molecule [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34505, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Stamprovided by FlyBase
    Official Full Name
    Signal transducing adaptor moleculeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027363
    Locus tag
    Dmel_CG6521
    See related
    AllianceGenome:FB:FBgn0027363
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6521; Dmel\CG6521; dstam; Dstam; stam; STAM; Stam1
    Summary
    Predicted to enable ubiquitin binding activity. Involved in several processes, including epithelial cell migration, open tracheal system; neuron remodeling; and regulation of epithelial cell migration, open tracheal system. Predicted to be part of ESCRT-0 complex. Is expressed in several structures, including female germline cell; ganglia; larval ventral midline glial cell; midline primordium; and ventral midline of embryo. Orthologous to several human genes including STAM (signal transducing adaptor molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Stam in Genome Data Viewer
    Location:
    32B2-32B3; 2-43 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10858536..10862006)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10858536..10862006)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene SET and MYND domain containing, arthropod-specific, member 3 Neighboring gene DNZDHHC/NEW1 zinc finger protein 11 Neighboring gene aurora B Neighboring gene long non-coding RNA:CR43807 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. STAM/EAST/Hbp adapter proteins--integrators of signalling pathways. Lohi O, et al. FEBS Lett, 2001 Nov 23. PMID 11728436
    2. VHS domain -- a longshoreman of vesicle lines. Lohi O, et al. FEBS Lett, 2002 Feb 20. PMID 11911875
    3. The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis. Bischoff JR, et al. Trends Cell Biol, 1999 Nov. PMID 10511710
    4. dSTAM expression pattern during wild type and mutant egg chamber development in D. melanogaster. Galasso A, et al. Gene Expr Patterns, 2007 Aug. PMID 17664083
    5. Depletion of ESCRT ameliorates APP-induced AD-like symptoms in Drosophila. Zhuang L, et al. J Cell Physiol, 2023 Jul. PMID 37183375

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results reveal that ESCRT-0 (ESCRT-0 components stam and hrs)mutants inhibit EGFR signaling by disrupting Rhomboid endosomal trafficking in the ligand-producing cells.
      Title: ESCRT-0 complex modulates Rbf-mutant cell survival by regulating Rhomboid endosomal trafficking and EGFR signaling.
    2. 2 Drosophila epithelia lacking Stam, or Hrs and Stam, accumulate Notch and Dome in endosomes, maintain normal apico-basal polarity and proliferation control and do not show ectopic Notch signaling activation.
      Title: ESCRT-0 is not required for ectopic Notch activation and tumor suppression in Drosophila.
    3. analysis of dSTAM expression pattern during wild type and mutant egg chamber development in D. melanogaster
      Title: dSTAM expression pattern during wild type and mutant egg chamber development in D. melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosomal transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosomal transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in epithelial cell migration, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron remodeling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of epithelial cell migration, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wound healing HMP PubMed 
    Component Evidence Code Pubs
    part_of ESCRT-0 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESCRT-0 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    signal transducing adaptor molecule
    Names
    CG6521-PA
    Stam-PA
    signal transducer adaptor molecule
    signal-transducing adaptor molecule

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10858536..10862006
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058100.4 → NP_477448.1  signal transducing adaptor molecule [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477448.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XTL2
      Related
      FBpp0079732
      Conserved Domains (3) summary
      cd11820
      Location:235 → 288
      SH3_STAM; Src homology 3 domain of Signal Transducing Adaptor Molecules
      cd03568
      Location:10 → 154
      VHS_STAM; VHS domain family, STAM subfamily; members include STAM (Signal Transducing Adaptor Molecule), EAST (EGFR-associated protein with SH3 and TAM domains) and Hbp (Hrs-binding protein). Collectively, they are referred to as STAM. All STAMs have at their ...
      pfam03127
      Location:340 → 412
      GAT; GAT domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XTL2 Q9XTL2

    Gene LinkOut

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