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    NP2 NPK1-related protein kinase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841937, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NP2
    Official Full Name
    NPK1-related protein kinase 2
    Primary source
    TAIR:AT1G54960
    Locus tag
    AT1G54960
    See related
    Araport:AT1G54960
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ANP2; F14C21.49; F14C21_49; MAPKKK2; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASES 2; NPK1-related protein kinase 2
    Summary
    member of MEKK subfamily
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    Genomic context

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    See NP2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    18
    Sequence:
    Chromosome: 1; NC_003070.9 (20499776..20504076)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene proline-rich protein 1 Neighboring gene Plant invertase/pectin methylesterase inhibitor superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proteomic and biochemical analyses show a functional network of proteins involved in antioxidant defense of the Arabidopsis anp2anp3 double mutant. Takáč T, et al. J Proteome Res, 2014 Dec 5. PMID 25325904, Free PMC Article
    2. An Arabidopsis mitogen-activated protein kinase kinase kinase gene family encodes essential positive regulators of cytokinesis. Krysan PJ, et al. Plant Cell, 2002 May. PMID 12034900, Free PMC Article
    3. Possible involvement of differential splicing in regulation of the activity of Arabidopsis ANP1 that is related to mitogen-activated protein kinase kinase kinases (MAPKKKs). Nishihama R, et al. Plant J, 1997 Jul. PMID 9263451
    4. Arabidopsis homologs of nucleus- and phragmoplast-localized kinase 2 and 3 and mitogen-activated protein kinase 4 are essential for microtubule organization. Beck M, et al. Plant Cell, 2010 Mar. PMID 20215588, Free PMC Article
    5. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that the functional network of proteins involved in antioxidant defense in the MAPK kinase kinases (MAPKKK) anp2anp3 mutant was physiologically linked with the increased resistance of mutant seedlings against paraquat treatment.
      Title: Proteomic and biochemical analyses show a functional network of proteins involved in antioxidant defense of the Arabidopsis anp2anp3 double mutant.
    2. ANP2/ANP3, MPK4, and the MT-associated protein MAP65-1 are involved in microtubule-dependent cell growth mechanisms.
      Title: Arabidopsis homologs of nucleus- and phragmoplast-localized kinase 2 and 3 and mitogen-activated protein kinase 4 are essential for microtubule organization.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001333684.1
    NM_104370.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables MAP kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within cortical microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cortical microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cytokinesis by cell plate formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    NPK1-related protein kinase 2
    NP_001319236.1
    • NPK1-related protein kinase 2 (NP2); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase-like domain (InterPro:IPR011009), Mitogen activated protein kinase kinase kinase 3 (InterPro:IPR015748), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: NPK1-related protein kinase 1 (TAIR:AT1G09000.1); Has 135537 Blast hits to 133200 proteins in 4901 species: Archae - 150; Bacteria - 15240; Metazoa - 51035; Fungi - 12941; Plants - 33422; Viruses - 585; Other Eukaryotes - 22164 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      20499776..20504076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001333684.1 → NP_001319236.1  NPK1-related protein kinase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4HYM4, O22041, Q9C7M0, Q9FZ36
      UniProtKB/TrEMBL
      A0A178WKE3, A0A5S9WRU2, A0A654EII3
      Conserved Domains (1) summary
      cd06606
      Location:67 → 330
      STKc_MAPKKK; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase Kinase Kinase

    2. NM_104370.5 → NP_175894.5  NPK1-related protein kinase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4HYM4, O22041, Q9C7M0, Q9FZ36
      UniProtKB/TrEMBL
      A0A178WKE3, A0A5S9WRU2, A0A654EII3
      Conserved Domains (1) summary
      cd06606
      Location:67 → 330
      STKc_MAPKKK; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase Kinase Kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FZ36.1

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