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    PMS1 DNA mismatch repair protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827997, updated on 18-Sep-2024

    Summary

    Official Symbol
    PMS1
    Official Full Name
    DNA mismatch repair protein
    Primary source
    TAIR:AT4G02460
    Locus tag
    AT4G02460
    See related
    Araport:AT4G02460
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtPMS1; ATPMS1; POSTMEIOTIC SEGREGATION 1; T14P8.6; T14P8_6
    Summary
    Encodes a protein similar to PMS1 in yeast, a member of the family of eukaryotic MutL homologs. The protein appears to play a role in DNA mismatch repair and in the suppression of somatic homeologous recombination.
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    Genomic context

    See PMS1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    11
    Sequence:
    Chromosome: 4; NC_003075.7 (1076090..1080727, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene HSP20-like chaperones superfamily protein Neighboring gene F-box family protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene AAA-type ATPase family protein Neighboring gene translocase of chloroplast-like protein Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein

    Bibliography

    Pathways from PubChem

    General gene information

    NM_001340378.1
    NM_001340379.1
    NM_001340380.1
    NM_116479.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mismatched DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within fruit development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mismatch repair IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mismatch repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within pollen development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within seed development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of mismatch repair complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IC
    Inferred by Curator
    more info
    PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
     

    General protein information

    Preferred Names
    DNA mismatch repair protein
    NP_567236.1
    • POSTMEIOTIC SEGREGATION 1 (PMS1); FUNCTIONS IN: mismatched DNA binding, ATP binding; INVOLVED IN: mismatch repair, fruit development, seed development, DNA recombination, pollen development; LOCATED IN: nucleus; EXPRESSED IN: 17 plant structures; EXPRESSED DURING: 9 growth stages; CONTAINS InterPro DOMAIN/s: DNA mismatch repair, conserved site (InterPro:IPR014762), ATPase-like, ATP-binding domain (InterPro:IPR003594), DNA mismatch repair protein, C-terminal (InterPro:IPR013507), MutL, C-terminal, dimerisation (InterPro:IPR014790), DNA mismatch repair protein, N-terminal (InterPro:IPR014763), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568), DNA mismatch repair protein (InterPro:IPR002099), Post Meiotic Segregation 2 (InterPro:IPR015434), Ribosomal protein S5 domain 2-type fold, subgroup (InterPro:IPR014721); BEST Arabidopsis thaliana protein match is: MUTL-homologue 1 (TAIR:AT4G09140.1); Has 10471 Blast hits to 7086 proteins in 2377 species: Archae - 138; Bacteria - 7516; Metazoa - 568; Fungi - 666; Plants - 148; Viruses - 0; Other Eukaryotes - 1435 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      1076090..1080727 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116479.4NP_567236.1  DNA mismatch repair protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567236.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81287, Q8GY98, Q941I6
      UniProtKB/TrEMBL
      A0A5S9XP74
      Conserved Domains (4) summary
      smart00853
      Location:707863
      MutL_C; MutL C terminal dimerisation domain
      COG0323
      Location:16895
      MutL; DNA mismatch repair ATPase MutL [Replication, recombination and repair]
      cd03484
      Location:224349
      MutL_Trans_hPMS_2_like; MutL_Trans_hPMS2_like: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to human PSM2 (hPSM2). hPSM2 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second ...
      cl00075
      Location:37141
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    2. NM_001340378.1NP_001329306.1  DNA mismatch repair protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B7A7, A0A5S9XP74
    3. NM_001340380.1NP_001329304.1  DNA mismatch repair protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B7A4, A0A5S9XP74
    4. NM_001340379.1NP_001329305.1  DNA mismatch repair protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B7A8