IRX1 cellulose synthase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: IRX1
Official Full Name: cellulose synthase family protein
Primary source: TAIR:AT4G18780
Locus tag: AT4G18780
See related: Araport:AT4G18780
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATCESA8; CELLULOSE SYNTHASE 8; CESA8; F28A21.190; F28A21_190; IRREGULAR XYLEM 1; LEAF WILTING 2; LEW2
Summary: Encodes a member of the cellulose synthase family involved in secondary cell wall biosynthesis. Mutants have abnormal xylem formation, reduced cellulose content, and enhanced drought and osmotic stress tolerance. Mediates resistance towards bacterial pathogens via ABA. Confers resistance towards bacterial and fungal pathogens, independent of salicylic acid, ethylene and jasmonate signaling.
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Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

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CESA8 role in the cellulose microfibril biosynthesis in the secondary cell wall.
Title: Exploiting CELLULOSE SYNTHASE (CESA) Class Specificity to Probe Cellulose Microfibril Biosynthesis.
The isolation and characterization of new alleles of the IRX1 gene with an increased tolerance to water stress are reported.
Title: Disruption of the cellulose synthase gene, AtCesA8/IRX1, enhances drought and osmotic stress tolerance in Arabidopsis.
Microarrays have been used to identify genes that exhibit a similar expression pattern to the secondary cell wall-specific cellulose synthase genes IRX1 and IRX3.
Title: Identification of novel genes in Arabidopsis involved in secondary cell wall formation using expression profiling and reverse genetics.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_117994.4

Function	Evidence Code	Pubs
enables cellulose synthase (UDP-forming) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cellulose synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cellulose synthase activity	ISS Inferred from Sequence or Structural Similarity more info
enables glycosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
NOT involved_in cell wall thickening	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellulose biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in ethylene-activated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
NOT involved_in jasmonic acid mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within plant-type secondary cell wall biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of abscisic acid biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to water deprivation	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in salicylic acid mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in plant-type cell wall	HDA more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

NP_567564.1

IRREGULAR XYLEM 1 (IRX1); FUNCTIONS IN: cellulose synthase activity, transferase activity, transferring glycosyl groups; INVOLVED IN: in 7 processes; LOCATED IN: cell wall, plasma membrane; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 9 growth stages; CONTAINS InterPro DOMAIN/s: Cellulose synthase (InterPro:IPR005150); BEST Arabidopsis thaliana protein match is: cellulose synthase A4 (TAIR:AT5G44030.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).