Drp1 Dynamin related protein 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Drp1provided by FlyBase
Official Full Name: Dynamin related protein 1provided by FlyBase
Primary source: FLYBASE:FBgn0026479
Locus tag: Dmel_CG3210
See related: AllianceGenome:FB:FBgn0026479
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3210; Dmel\CG3210; Dnm1/Drp1; DNM1L; drp; Drp; DRP; drp-1; Drp-1; drp1; DRP1; frat; l(2)22Fc; l(2)22Fd; l(2)ND2; l(2)ND3
Summary: Predicted to enable GTPase activity and microtubule binding activity. Involved in several processes, including mitochondrion organization; positive regulation of mitochondrial fission; and ventral furrow formation. Acts upstream of with a positive effect on lymph gland crystal cell differentiation. Located in mitochondrion. Is expressed in adult head. Human ortholog(s) of this gene implicated in encephalopathy due to defective mitochondrial and peroxisomal fission 1 and optic atrophy 5. Orthologous to human DNM1L (dynamin 1 like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 23A1-23A1; 2-7 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (2581281..2585430, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (2581281..2585430, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Compartment specific mitochondrial dysfunction in Drosophila knock-in model of ALS reversed by altered gene expression of OXPHOS subunits and pro-fission factor Drp1.
Title: Compartment specific mitochondrial dysfunction in Drosophila knock-in model of ALS reversed by altered gene expression of OXPHOS subunits and pro-fission factor Drp1.
Differential mitochondrial roles for alpha-synuclein in DRP1-dependent fission and PINK1/Parkin-mediated oxidation.
Title: Differential mitochondrial roles for α-synuclein in DRP1-dependent fission and PINK1/Parkin-mediated oxidation.
Mitochondrial morphology and activity regulate furrow ingression and contractile ring dynamics in Drosophila cellularization.
Title: Mitochondrial morphology and activity regulate furrow ingression and contractile ring dynamics in Drosophila cellularization.
Drosophila phosphatidylinositol-4 kinase fwd promotes mitochondrial fission and can suppress Pink1/parkin phenotypes.
Title: Drosophila phosphatidylinositol-4 kinase fwd promotes mitochondrial fission and can suppress Pink1/parkin phenotypes.
The reduced expression of Parkin and HtrA2 interpret defective mitophagy leading to clustering of fragmented mitochondria and apoptotic inhibition in scrib knockdown tumors.
Title: scribble (scrib) knockdown induces tumorigenesis by modulating Drp1-Parkin mediated mitochondrial dynamics in the wing imaginal tissues of Drosophila.
Data show that short-term induction of Drp1, in midlife, is sufficient to improve organismal health and prolong lifespan.
Title: Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster.
Study showed that exogenous expression of Drp1 could promote crawling ability, reduced the level of ATP in Drosophila brain and suppressed neuronal degeneration, suggesting that Drp1 is involved in the pathogenesis of Alzheimer disease.
Title: Exogenous expression of Drp1 plays neuroprotective roles in the Alzheimer's disease in the Aβ42 transgenic Drosophila model.
Results show that centronuclear myopathy associated Dyn2 mutants are gain-of-function mutations, and their primary effect in muscle is T-tubule disorganization, which explains the susceptibility of muscle to Dyn2 hyperactivity.
Title: Dynamin-2 mutations associated with centronuclear myopathy are hypermorphic and lead to T-tubule fragmentation.
Debcl modulates Drp1 mitochondrial localization during apoptosis.
Title: The Drosophila retinoblastoma protein, Rbf1, induces a Debcl- and Drp1-dependent mitochondrial apoptosis.
Thus, DRP1-dependent mitochondrial fission activity is a novel regulator of the onset of follicle cell differentiation during Drosophila
Title: DRP1-dependent mitochondrial fission initiates follicle cell differentiation during Drosophila oogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular distribution of mitochondria	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_positive_effect lymph gland crystal cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitochondrial fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial fission	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitochondrial fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peroxisome fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mitochondrial fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitochondrial fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral furrow formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dynamin related protein 1

Names: CG3210-PA; CG3210-PB; Drp1-PA; Drp1-PB; dynamin related protein-1; dynamin-2; dynamin-related protein; dynamin-related protein 1; dynaminrelated protein 1; fratboy; lethal(2)22Fc; lethal(2)22Fd; near dpp complementation group 2; near dpp complementation group 3; noodle

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

2581281..2585430 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273017.1 → NP_001259946.1 dynamin related protein 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259946.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IHG0, Q9VQE0

Conserved Domains (4) summary

cd08771
Location:23 → 301

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

COG0699
Location:88 → 728

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

pfam01031
Location:226 → 507

Dynamin_M; Dynamin central region

pfam02212
Location:643 → 729

GED; Dynamin GTPase effector domain
NM_134850.3 → NP_608694.2 dynamin related protein 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_608694.2

Status: REVIEWED

UniProtKB/TrEMBL

Q8IHG0, Q9VQE0

Related

FBpp0077424

Conserved Domains (4) summary

cd08771
Location:23 → 301

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

COG0699
Location:88 → 728

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

pfam01031
Location:226 → 507

Dynamin_M; Dynamin central region

pfam02212
Location:643 → 729

GED; Dynamin GTPase effector domain