GBF6 G-box binding factor 6 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: GBF6
Official Full Name: G-box binding factor 6
Primary source: TAIR:AT4G34590
Locus tag: AT4G34590
See related: Araport:AT4G34590
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: Arabidopsis thaliana basic leucine-zipper 11; ATB2; AtbZIP11; ATBZIP11; BZIP11; G-box binding factor 6; T4L20.170; T4L20_170
Summary: Encodes a basic domain leucine zipper (bZip) transcription factor bZIP11. Translation is repressed by sucrose. Directly regulates gene expression of ASN1 and ProDH2, which are enzyme-coding genes involved in amino acid metabolism.
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Genomic context

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See GBF6 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 1

Sequence:: Chromosome: 4; NC_003075.7 (16521861..16523230)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that bZIP11 uORF2 encodes a regulatory nascent peptide that functions to sense intracellular sucrose abundance.
Title: Sucrose sensing through nascent peptide-meditated ribosome stalling at the stop codon of Arabidopsis bZIP11 uORF2.
Based on ensuing molecular and biochemical analyses, we propose a mechanistic model, in which bZIP11-related TFs gain control over the root meristem by directly activating IAA3/SHY2 transcription. IAA3/SHY2 is a pivotal negative regulator of root growth, which has been demonstrated to efficiently repress transcription of major auxin transport facilitators of the PIN-FORMED (PIN) gene family, thereby restricting polar auxi
Title: The Arabidopsis bZIP11 transcription factor links low-energy signalling to auxin-mediated control of primary root growth.
Arabidopsis bZIP11-related basic leucine zipper (bZIP) transcription factors interact via an amino-terminal activation domain with ADA2b adapter proteins to recruit the histone acetylation machinery to specific auxin-responsive genes.
Title: The Arabidopsis transcription factor bZIP11 activates auxin-mediated transcription by recruiting the histone acetylation machinery.
The bZIP11 induction leads to reduced contents of the prominent growth regulatory molecule trehalose 6-phosphate (T6P). The metabolic changes detected mimic in part those observed in carbon-starved plants.
Title: The sucrose-regulated Arabidopsis transcription factor bZIP11 reprograms metabolism and regulates trehalose metabolism.
The uORF2 element in the bZip11 mRNA encodes a sucrose control peptide that inhibits bZIP11 translation in response to high sucrose levels by stalling the ribosome on the mRNA.
Title: Sucrose control of translation mediated by an upstream open reading frame-encoded peptide.
bZIP11 target processes are identified using transiently increased nuclear bZIP11 levels and genome-wide expression analysis; the effect of bZIP11 on ASN1 and GBF6 are reported.
Title: The sucrose regulated transcription factor bZIP11 affects amino acid metabolism by regulating the expression of ASPARAGINE SYNTHETASE1 and PROLINE DEHYDROGENASE2.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Miscellaneous features

Loc: 16522098-16522226 AT4G34590.uORF1

NM_119625.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to sucrose	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within sucrose induced translational repression	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: G-box binding factor 6

NP_195185.1

G-box binding factor 6 (GBF6); FUNCTIONS IN: DNA binding, protein heterodimerization activity, sequence-specific DNA binding transcription factor activity; INVOLVED IN: sucrose induced translational repression, negative regulation of translation, regulation of transcription, DNA-dependent, response to sucrose stimulus; LOCATED IN: chloroplast; CONTAINS InterPro DOMAIN/s: Basic-leucine zipper (bZIP) transcription factor (InterPro:IPR004827), bZIP transcription factor, bZIP-1 (InterPro:IPR011616); BEST Arabidopsis thaliana protein match is: basic leucine-zipper 44 (TAIR:AT1G75390.1); Has 1778 Blast hits to 1778 proteins in 91 species: Archae - 0; Bacteria - 0; Metazoa - 8; Fungi - 2; Plants - 1730; Viruses - 0; Other Eukaryotes - 38 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

16521861..16523230

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_119625.3 → NP_195185.1 G-box binding factor 6 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_195185.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O65683, P94060

UniProtKB/TrEMBL

A0A178UVA0, A0A5S9XYL3, A0A654FVJ4

Conserved Domains (1) summary

cd14702
Location:28 → 78

bZIP_plant_GBF1; Basic leucine zipper (bZIP) domain of Plant G-box binding factor 1 (GBF1)-like transcription factors: a DNA-binding and dimerization domain