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    CAF1a Polynucleotidyl transferase, ribonuclease H-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823551, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CAF1a
    Official Full Name
    Polynucleotidyl transferase, ribonuclease H-like superfamily protein
    Primary source
    TAIR:AT3G44260
    Locus tag
    AT3G44260
    See related
    Araport:AT3G44260
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtCAF1a; CCR4- associated factor 1a
    Summary
    Encodes one of the homologs of the yeast CCR4-associated factor 1: AT3G44260 (CAF1a), AT5G22250 (CAF1b). Has mRNA deadenylation activity. Also plays a role in plant defense responses.
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    Genomic context

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    See CAF1a in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    1
    Sequence:
    Chromosome: 3; NC_003074.8 (15952008..15953346, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene cytochrome P450, family 71, subfamily B, polypeptide 38 Neighboring gene Pol polyprotein/retrotransposon Neighboring gene beta-galactosidase-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis deadenylases AtCAF1a and AtCAF1b play overlapping and distinct roles in mediating environmental stress responses. Walley JW, et al. Plant Physiol, 2010 Feb. PMID 19955262, Free PMC Article
    2. The Arabidopsis homologs of CCR4-associated factor 1 show mRNA deadenylation activity and play a role in plant defence responses. Liang W, et al. Cell Res, 2009 Mar. PMID 19065152
    3. Identification of Arabidopsis CCR4-NOT Complexes with Pumilio RNA-Binding Proteins, APUM5 and APUM2. Arae T, et al. Plant Cell Physiol, 2019 Sep 1. PMID 31093672
    4. Mechanical stress induces biotic and abiotic stress responses via a novel cis-element. Walley JW, et al. PLoS Genet, 2007 Oct. PMID 17953483, Free PMC Article
    5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtCAF1a and AtCAF1b regulate abiotic stress responses. However, AtCAF1a and AtCAF1b are not functionally redundant in all cases, nor are they essential for all environmental stresses. AtCAF1b is required for deadenylation of mRNA. [CAF1a]
      Title: Arabidopsis deadenylases AtCAF1a and AtCAF1b play overlapping and distinct roles in mediating environmental stress responses.
    2. These results suggest roles of the AtCAF1 proteins in regulated mRNA deadenylation and defence responses to pathogen infections.[AtCAF1a]
      Title: The Arabidopsis homologs of CCR4-associated factor 1 show mRNA deadenylation activity and play a role in plant defence responses.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_114294.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 3'-5' exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables poly(A)-specific ribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to insect IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within nuclear-transcribed mRNA poly(A) tail shortening IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CCR4-NOT complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Polynucleotidyl transferase, ribonuclease H-like superfamily protein
    NP_190012.1
    • Polynucleotidyl transferase, ribonuclease H-like superfamily protein; FUNCTIONS IN: ribonuclease activity, nucleic acid binding; INVOLVED IN: response to biotic stimulus, response to wounding, RNA modification; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Ribonuclease CAF1 (InterPro:IPR006941), Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337); BEST Arabidopsis thaliana protein match is: Polynucleotidyl transferase, ribonuclease H-like superfamily protein (TAIR:AT5G22250.1); Has 907 Blast hits to 905 proteins in 225 species: Archae - 0; Bacteria - 0; Metazoa - 261; Fungi - 149; Plants - 375; Viruses - 0; Other Eukaryotes - 122 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      15952008..15953346 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114294.3 → NP_190012.1  Polynucleotidyl transferase, ribonuclease H-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190012.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LXM2
      UniProtKB/TrEMBL
      A0A5S9XHM2, A0A654FI64
      Conserved Domains (1) summary
      cl23804
      Location:20 → 279
      CAF1; CAF1 family ribonuclease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LXM2.1

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