ATM Serine/Threonine-kinase ATM-like protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ATM
Official Full Name: Serine/Threonine-kinase ATM-like protein
Primary source: TAIR:AT3G48190
Locus tag: AT3G48190
See related: Araport:AT3G48190
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA ATAXIA-TELANGIECTASIA MUTATED; ATATM; ataxia-telangiectasia mutated; pcd in male gametogenesis 1; PIG1
Summary: Encodes a homolog of the human ATM gene, which is mutated in ataxia telangiectasia, a chromosome instability disorder. Characterization of mutants suggest a role in repairing DNA in response to ionizing radiation as well as during meiosis. The protein has kinase domains and shows kinase activity in orthologs. There is also evidence that ATM might be involved in the telomerase-independent process known as Alternative Lengthening of Telomeres.
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Genomic context

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See ATM in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 77

Sequence:: Chromosome: 3; NC_003074.8 (17801289..17828553)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ATM and ATR, two central players of the DNA damage response, are involved in the induction of systemic acquired resistance by extracellular DNA, but not the plant wound response.
Title: ATM and ATR, two central players of the DNA damage response, are involved in the induction of systemic acquired resistance by extracellular DNA, but not the plant wound response.
Roles of MEM1 in safeguarding Arabidopsis genome against DNA damage, inhibiting ATM/SOG1-mediated DNA damage response, and antagonizing global DNA hypermethylation.
Title: Roles of MEM1 in safeguarding Arabidopsis genome against DNA damage, inhibiting ATM/SOG1-mediated DNA damage response, and antagonizing global DNA hypermethylation.
ATM controls meiotic DNA double-strand break formation and recombination and affects synaptonemal complex organization in plants.
Title: ATM controls meiotic DNA double-strand break formation and recombination and affects synaptonemal complex organization in plants.
ATM suppresses leaf senescence triggered by DNA double-strand break through epigenetic control of senescence-associated genes in Arabidopsis.
Title: ATM suppresses leaf senescence triggered by DNA double-strand break through epigenetic control of senescence-associated genes in Arabidopsis.
These data outline a protective mechanism for DNA damage repair and the restoration of mitochondrial function that involves RUG3-mediated mitochondrial retrograde signaling and the activation of an ATM-mediated DNA damage response pathway via modulating the alternative splicing of nad2.
Title: RUG3 and ATM synergistically regulate the alternative splicing of mitochondrial nad2 and the DNA damage response in Arabidopsis thaliana.
Mutant ATR and ATM seeds are highly resistant to aging, establishing ATM and ATR as determinants of seed viability.
Title: DNA damage checkpoint kinase ATM regulates germination and maintains genome stability in seeds.
ATM-dependent DNA damage response acts as an upstream trigger in fas1 to delay the cell cycle and promote entry into the endocycle, resulting in compensated cell expansion.
Title: The ATM-dependent DNA damage response acts as an upstream trigger for compensation in the fas1 mutation during Arabidopsis leaf development.
The genome stability of the Arabidopsis thaliana mutants deficient in ATM (communication between DNA strand break recognition and the repair machinery), KU80 (deficient in NHEJ) and RAD51B (deficient in HR repair) genes, was investigated.
Title: Genome stability of Arabidopsis atm, ku80 and rad51b mutants: somatic and transgenerational responses to stress.
Short telomeres in tert mutant plants activate both ATM and ATR. Absence of telomerase elicits and ATM and ATR-dependent DNA damage response at telomeres.
Title: Arabidopsis ATM and ATR kinases prevent propagation of genome damage caused by telomere dysfunction.
cooperation among DNA translesion synthesis (TLS) polymerases (Poleta, Polzeta) and DNA-damage-activated protein kinases (ATR, ATM)
Title: Cooperative responses of DNA-damage-activated protein kinases ATR and ATM and DNA translesion polymerases to replication-blocking DNA damage in a stem-cell niche.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001339354.1

Supported by ESTs:

NM_001339355.1

Supported by ESTs:

NM_001339356.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-phosphate 5-kinase activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in RNA splicing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within double-strand break repair via nonhomologous end joining	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within double-strand break repair via synthesis-dependent strand annealing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homologous chromosome pairing at meiosis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organismal reproductive process	IGI Inferred from Genetic Interaction more info	PubMed
NOT involved_in reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of chromosome organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of telomere maintenance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to gamma radiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to ionizing radiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within telomere maintenance in response to DNA damage	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info
located_in plasmodesma	HDA more info	PubMed

General protein information

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Preferred Names: Serine/Threonine-kinase ATM-like protein

NP_001319707.1

ataxia-telangiectasia mutated (ATM); FUNCTIONS IN: 1-phosphatidylinositol-3-phosphate 5-kinase activity; INVOLVED IN: in 8 processes; LOCATED IN: chloroplast; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Phosphatidylinositol 3-/4-kinase, catalytic (InterPro:IPR000403), PIK-related kinase, FAT (InterPro:IPR003151), Ataxia-Telangiectasia Mutated (InterPro:IPR015519), PIK-related kinase (InterPro:IPR014009), PWWP (InterPro:IPR000313), PIK-related kinase, FATC (InterPro:IPR003152), Phosphatidylinositol 3/4-kinase, conserved site (InterPro:IPR018936), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: Ataxia telangiectasia-mutated and RAD3-related (TAIR:AT5G40820.1); Has 3479 Blast hits to 3364 proteins in 268 species: Archae - 0; Bacteria - 7; Metazoa - 1400; Fungi - 858; Plants - 531; Viruses - 0; Other Eukaryotes - 683 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

17801289..17828553

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001339354.1 → NP_001319707.1 Serine/Threonine-kinase ATM-like protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A654FDU7
NM_001339355.1 → NP_001326746.1 Serine/Threonine-kinase ATM-like protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1I9LQ79, A0A654FDU7
NM_001339356.1 → NP_001326745.1 Serine/Threonine-kinase ATM-like protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1I9LQ78, A0A654FDU7