SCR GRAS family transcription factor [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SCR
Official Full Name: GRAS family transcription factor
Primary source: TAIR:AT3G54220
Locus tag: AT3G54220
See related: Araport:AT3G54220
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: SCARECROW; SGR1; SHOOT GRAVITROPISM 1
Summary: Encodes a member of a novel family having similarity to DNA binding proteins containing basic-leucine zipper regions; scr is expressed in cortex/endodermal initial cells and in the endodermal cell lineage. Regulates the radial organization of the root. Is required cell-autonomously for distal specification of the quiescent center, which in turn regulates stem cell fate of immediately surrounding cells. SCR appears to be a direct target of SHR.
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Genomic context

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See SCR in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 2

Sequence:: Chromosome: 3; NC_003074.8 (20069987..20072878)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SHR and SCR coordinate root patterning and growth early in the cell cycle.
Title: SHR and SCR coordinate root patterning and growth early in the cell cycle.
SCARECROW maintains the stem cell niche in Arabidopsis roots by ensuring telomere integrity.
Title: SCARECROW maintains the stem cell niche in Arabidopsis roots by ensuring telomere integrity.
SHORT-ROOT and SCARECROW homologs regulate patterning of diverse cell types within and between species.
Title: SHORT-ROOT and SCARECROW homologs regulate patterning of diverse cell types within and between species.
A mechanism coordinating root elongation, endodermal differentiation, redox homeostasis and stress response.
Title: A mechanism coordinating root elongation, endodermal differentiation, redox homeostasis and stress response.
Gene Regulation via the Combination of Transcription Factors in the INDETERMINATE DOMAIN and GRAS Families.
Title: Gene Regulation via the Combination of Transcription Factors in the INDETERMINATE DOMAIN and GRAS Families.
SCR expression and role in the root epidermal differentiation.
Title: Histone Deacetylase HDA19 Affects Root Cortical Cell Fate by Interacting with SCARECROW.
This study showed that INDETERMINATE DOMAIN PROTEIN (ID) binding sequences have a crucial role in the regulation of SCARECROW and SHORT-ROOT expression.[SCARECROW]
Title: INDETERMINATE DOMAIN PROTEIN binding sequences in the 5'-untranslated region and promoter of the SCARECROW gene play crucial and distinct roles in regulating SCARECROW expression in roots and leaves.
In the crystal structures of the SHR-SCR binary and JACKDAW (JKD)/IDD10-SHR-SCR ternary complexes, each GRAS domain comprises one alpha/beta core subdomain with an alpha-helical cap that mediates heterodimerization by forming an intermolecular helix bundle.
Title: Structure of the SHR-SCR heterodimer bound to the BIRD/IDD transcriptional factor JKD.
SCR and PLETHORA genetically and physically interact with plant-specific teosinte-branched cycloidea PCNA (TCP) transcription factors to specify the stem cell niche during embryogenesis and maintain organizer cells post-embryonically.
Title: Root stem cell niche organizer specification by molecular convergence of PLETHORA and SCARECROW transcription factor modules.
results provide new insights into the regulatory role of the SHR-SCR-SCL23 network in the endodermis development in both roots and shoots.
Title: Conservation and Diversification of the SHR-SCR-SCL23 Regulatory Network in the Development of the Functional Endodermis in Arabidopsis Shoots.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_115282.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
NOT enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within asymmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bundle sheath cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell redox homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gravitropism	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within leaf development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within maintenance of protein location in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within radial pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within root development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: GRAS family transcription factor

NP_190990.1

SCARECROW (SCR); CONTAINS InterPro DOMAIN/s: Transcription factor GRAS (InterPro:IPR005202); BEST Arabidopsis thaliana protein match is: GRAS family transcription factor (TAIR:AT5G41920.1); Has 4362 Blast hits to 4213 proteins in 491 species: Archae - 0; Bacteria - 22; Metazoa - 838; Fungi - 368; Plants - 2661; Viruses - 19; Other Eukaryotes - 454 (source: NCBI BLink).