kermit kermit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: kermitprovided by FlyBase
Official Full Name: kermitprovided by FlyBase
Primary source: FLYBASE:FBgn0010504
Locus tag: Dmel_CG11546
See related: AllianceGenome:FB:FBgn0010504
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BEST:LD04728; CG11546; dGIPC; dKermit; Dmel\CG11546; l(2)02045; LD04728
Summary: Enables G-protein alpha-subunit binding activity. Involved in establishment of planar polarity and motor neuron axon guidance. Colocalizes with vesicle. Is expressed in several structures, including embryonic anal pad; embryonic/larval midgut; glial cell; head mesoderm; and plasmatocyte primordium. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 15 and oculopharyngodistal myopathy 2. Orthologous to several human genes including GIPC3 (GIPC PDZ domain containing family member 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 44B5-44B5; 2-58 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (8146918..8156654, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (4034423..4044159, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that Kermit interacts with Go and another PCP component Vang during planar cell polarity (PCP).
Title: Kermit interacts with Gαo, Vang, and motor proteins in Drosophila planar cell polarity.
a non-essential role of dGIPC in viability and normal Drosophila development
Title: The Drosophila GIPC homologue can modulate myosin based processes and planar cell polarity but is not essential for development.
DrosophiladGIPC acts in the adult central nervous system and may be required to regulate the trafficking of dopamine receptors needed for proper functioning of dopaminergic neurons.
Title: dGIPC is required for the locomotive activity and longevity in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G-protein alpha-subunit binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
NOT involved_in Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: kermit

Names: CG11546-PA; CG11546-PB; CG11546-PC; CG11546-PD; CG11546-PE; kermit-PA; kermit-PB; kermit-PC; kermit-PD; kermit-PE; lethal (2) 02045

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

8146918..8156654 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_165590.3 → NP_724649.1 kermit, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724649.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JX82

Related

FBpp0087888

Conserved Domains (1) summary

cd00992
Location:126 → 207

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_143771.4 → NP_652028.1 kermit, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_652028.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JX82

Related

FBpp0087887

Conserved Domains (1) summary

cd00992
Location:126 → 207

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_165592.3 → NP_724651.1 kermit, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724651.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JX82

Related

FBpp0087889

Conserved Domains (1) summary

cd00992
Location:126 → 207

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_165591.3 → NP_724650.1 kermit, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724650.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JX82

Related

FBpp0087890

Conserved Domains (1) summary

cd00992
Location:126 → 207

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001299258.1 → NP_001286187.1 kermit, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286187.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JX82

Conserved Domains (1) summary

cd00992
Location:126 → 207

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...