PEX1 peroxisome 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PEX1
Official Full Name: peroxisome 1
Primary source: TAIR:AT5G08470
Locus tag: AT5G08470
See related: Araport:AT5G08470
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: EMB2817; EMBRYO DEFECTIVE 2817; F8L15.15; peroxisome 1
Summary: an AAA-ATPase that is the probable Arabidopsis orthologue of one of the AAA-ATPases involved in peroxisome biogenesis in yeasts and mammals.
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Genomic context

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See PEX1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 18

Sequence:: Chromosome: 5; NC_003076.8 (2735911..2743065)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

beyond PEX5 recycling, PEX1 and PEX6 have additional functions in peroxisome homeostasis and perhaps in oil body utilization
Title: A pex1 missense mutation improves peroxisome function in a subset of Arabidopsis pex6 mutants without restoring PEX5 recycling.
genetic, molecular, and physiological data support the heterohexamer model of PEX1-PEX6 function in plants.
Title: The PEX1 ATPase Stabilizes PEX6 and Plays Essential Roles in Peroxisome Biology.
PEX1 and PEX6 comprise a heterooligomer and this complex was recruited to peroxisomal membranes via protein-protein interactions of APEM9 with PEX6.
Title: Arabidopsis ABERRANT PEROXISOME MORPHOLOGY9 is a peroxin that recruits the PEX1-PEX6 complex to peroxisomes.

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General gene information

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NM_001343003.1

Supported by ESTs:

NM_001343004.1

Supported by ESTs:

NM_001343005.1

Supported by ESTs:

NM_120932.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within fatty acid beta-oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peroxisome organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein import into peroxisome matrix	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: peroxisome 1

NP_196464.2

peroxisome 1 (PEX1); FUNCTIONS IN: nucleoside-triphosphatase activity, ATPase activity, binding, nucleotide binding, ATP binding; INVOLVED IN: protein import into peroxisome matrix, fatty acid beta-oxidation, response to stress; LOCATED IN: peroxisome; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ATPase, AAA-type, core (InterPro:IPR003959), Aspartate decarboxylase-like fold (InterPro:IPR009010), ATPase, AAA-type, conserved site (InterPro:IPR003960), Peroxisome biogenesis factor 1, N-terminal (InterPro:IPR015342); BEST Arabidopsis thaliana protein match is: ATPase, AAA-type, CDC48 protein (TAIR:AT3G53230.1); Has 45022 Blast hits to 26157 proteins in 3042 species: Archae - 1897; Bacteria - 15808; Metazoa - 7500; Fungi - 5597; Plants - 4311; Viruses - 29; Other Eukaryotes - 9880 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

2735911..2743065

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_120932.3 → NP_196464.2 peroxisome 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_196464.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9FNP1, Q9FQ60

UniProtKB/TrEMBL

A0A5S9Y2I9, A0A654FZF7

Conserved Domains (4) summary

cd00009
Location:589 → 635

AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

COG0464
Location:585 → 1104

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

pfam00004
Location:881 → 1010

AAA; ATPase family associated with various cellular activities (AAA)

pfam09262
Location:109 → 182

PEX-1N; Peroxisome biogenesis factor 1, N-terminal
NM_001343003.1 → NP_001331459.1 peroxisome 1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8BDY2, A0A5S9Y2I9, A0A654FZF7
NM_001343004.1 → NP_001331458.1 peroxisome 1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8BDW7, A0A5S9Y2I9, A0A654FZF7
NM_001343005.1 → NP_001331457.1 peroxisome 1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8BDW6