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    CG14740 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41468, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG14740provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037988
    Locus tag
    Dmel_CG14740
    See related
    AllianceGenome:FB:FBgn0037988
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.178; CS; Dmel\CG14740
    Summary
    Predicted to enable citrate (Si)-synthase activity. Predicted to be involved in carbohydrate metabolic process and tricarboxylic acid cycle. Predicted to be active in mitochondrial matrix. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and hypertrophic cardiomyopathy. Orthologous to human CS (citrate synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG14740 in Genome Data Viewer
    Location:
    87A6-87A6; 3-51 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12061070..12062944, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7886792..7888666, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ATPase 8B Neighboring gene defective proboscis extension response 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [The effect of altered oxygen partial pressure on the resisitance to hypoxia and expression of oxygen-sensitive genes in Drosophila melanogaster]. Berezovs'kyĭ VIa, et al. Fiziol Zh (1994), 2014. PMID 25335240
    2. A Colorimetric Assay of Citrate Synthase Activity in Drosophila Melanogaster. Wei P, et al. J Vis Exp, 2020 Jan 16. PMID 32009637
    3. Review: Hypoxic and oxidative stress resistance in Drosophila melanogaster. Zhao HW, et al. Placenta, 2011 Mar. PMID 21353099, Free PMC Article
    4. Neuroprotective effect of geraniol and curcumin in an acrylamide model of neurotoxicity in Drosophila melanogaster: relevance to neuropathy. Prasad SN, et al. J Insect Physiol, 2014 Jan. PMID 24231732
    5. Genetic link between heme oxygenase and the signaling pathway of DNA damage in Drosophila melanogaster. Ida H, et al. Tohoku J Exp Med, 2013 Oct. PMID 24126234

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Low oxygen partial pressure of highly resistant Drosophila significantly reduces the time of restitution and increases the expression of Sir2 and CG14740 genes.
      Title: [The effect of altered oxygen partial pressure on the resisitance to hypoxia and expression of oxygen-sensitive genes in Drosophila melanogaster].
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acyltransferase activity, acyl groups converted into alkyl on transfer IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables citrate (Si)-synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG14740-PA
    citrate synthase
    NP_650152.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12061070..12062944 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141895.3 → NP_650152.1  uncharacterized protein Dmel_CG14740 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650152.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TZ4, Q9VGD5
      Related
      FBpp0082025
      Conserved Domains (2) summary
      cd06103
      Location:33 → 458
      ScCS-like; Saccharomyces cerevisiae (Sc) citrate synthase (CS)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). Some CS ...
      COG0372
      Location:67 → 454
      GltA; Citrate synthase [Energy production and conversion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95TZ4 Q95TZ4

    Gene LinkOut

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